Slit-Robo Signaling in Ocular Angiogenesis

  • Haoyu ChenEmail author
  • Mingzhi Zhang
  • Shibo Tang
  • Nyall R. London
  • Dean Y. Li
  • Kang Zhang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


Slit-Robo signaling was firstly discovered as a major repellent pathway at the midline of the central nervous system. Intense investigation found that this pathway also plays an important role in other biological process including angiogenesis. Robo4 is the vascular endothelial cell specific member of Robo family. It was found that Slit-Robo signaling can inhibit endothelial cell migration, tube formation and vascular permeability. Slit-Robo signaling also plays an important role in embryonic and tumor angiogenesis. In animal model of ocular angiogenesis, addition of Slit inhibited laser induced choroidal neovascularization, oxygen induced retinopathy and VEGF induced retinal permeability in a Robo4 dependent manner. Recent data demonstrates that Robo1 and Robo4 form a heterodimer in endothelial cells, The role of this heterodimer in counteracting VEGF signaling is unknown. Further investigation is required to better understand Slit-Robo signaling and develop novel therapy for angiogenesis.


Vascular Endothelial Growth Factor Proliferative Diabetic Retinopathy Choroidal Neovascularization Endothelial Cell Migration Retinal Vasculature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank the following support to HC: Kaisi Funds at Sun Yat-sen University, JSIEC Starting grants; to ST: National Key Science and Technology Project from ‘Tenth Five-Year Plan’ of China, National Natural Science Foundation of China; to KZ: National Institutes of Health Grants R01EY14428, R01EY14448, P30EY014800, and GCRCM01-RR00064, Foundation Fighting Blindness, the Macular Vision Research Foundation, Veterans Affairs Merit Award, and Research to Prevent Blindness to NRL: the Ruth L. Kirschstein National Research Service Award.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Haoyu Chen
    • 1
    • 2
    Email author
  • Mingzhi Zhang
    • 1
  • Shibo Tang
    • 3
  • Nyall R. London
    • 4
  • Dean Y. Li
    • 4
  • Kang Zhang
    • 2
    • 5
  1. 1.Joint Shantou International Eye CenterShantou University and the Chinese University of Hong KongShantouChina
  2. 2.Moran Eye CenterUniversity of UtahSalt Lake CityUSA
  3. 3.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouChina
  4. 4.Department of Oncological Sciences and Medicine and Program in Human Molecular Biology and GeneticsUniversity of UtahSalt Lake CityUSA
  5. 5.Institute for Genomic Medicine and Shiley Eye CenterUniversity of California at San DiegoLa JollaUSA

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