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The Pathophysiology of Cigarette Smoking and Age-Related Macular Degeneration

  • S.S. Ni Dhubhghaill
  • M.T. Cahill
  • M. Campbell
  • L. Cassidy
  • M.M. Humphries
  • P. Humphries
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)

Abstract

Age-related macular degeneration (AMD) is the most common form of visual impairment, in people over 65, in the Western world. AMD is a multifactorial disease with genetic and environmental factors influencing disease progression. Cigarette smoking is the most significant environmental influence with an estimated increase in risk of 2- to 4-fold. Smoke-induced damage in AMD is mediated through direct oxidation, depletion of antioxidant protection, immune system activation and atherosclerotic vascular changes. Moreover, cigarette smoke induces angiogenesis promoting choroidal neovascularisation and progression to neovascular AMD. Further investigation into the effects of cigarette smoke through in vitro and in vivo experimentation will provide a greater insight into the pathogenesis of age-related macular degeneration.

Keywords

Cigarette Smoke Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Cigarette Smoke Exposure Macular Pigment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work is supported by the Research Foundation of the Royal Victoria Eye and Ear Hospital, Dublin and the Irish Research Council for Science Engineering and Technology (IRCSET).

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • S.S. Ni Dhubhghaill
    • 1
  • M.T. Cahill
    • 1
  • M. Campbell
    • 1
  • L. Cassidy
    • 1
  • M.M. Humphries
    • 1
  • P. Humphries
    • 1
  1. 1.The Ocular Genetics Unit, Department of GeneticsTrinity College DublinDublin 2Ireland

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