PPAR Nuclear Receptors and Altered RPE Lipid Metabolism in Age-Related Macular Degeneration

  • Goldis Malek
  • Peng Hu
  • Albert Wielgus
  • Mary Dwyer
  • Scott Cousins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


The pathophysiology of ‘early’ dry age-related macular degeneration (ARMD), characterized by the accumulation of lipid and protein-rich sub-retinal deposits remains largely unknown. Accumulation and dysregulated turnover of lipids as well as extracellular matrix (ECM) molecules in sub-retinal pigment epithelial (RPE) deposits and Bruch’s membrane, itself an ECM, play a role in ARMD. Epidemiological studies have shown an increased risk for the disease associated with higher dietary intake of long chain poly-unsaturated fatty acids (LCPUFA) and specifically more so for n-6 versus n-3 fatty acids. PUFAs are membrane targets of lipid peroxidation and natural ligands for the nuclear receptors, peroxisome proliferator activated receptors (PPAR). Here we investigated the expression of genes involved in lipid metabolism and expression of the three isoforms of PPARs in an immortalized cell line of human RPE cells (ARPE19) in the presence or absence of fatty acids.


Retinal Pigment Epithelial Peroxisome Proliferator Activate Receptor Retinal Pigment Epithelial Cell ARPE19 Cell Human Retinal Pigment Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by a grant from the International Retinal Research Foundation and Research to Prevent Blindness.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Goldis Malek
    • 1
  • Peng Hu
    • 1
  • Albert Wielgus
    • 1
  • Mary Dwyer
    • 1
  • Scott Cousins
    • 1
    • 2
  1. 1.Department of OphthalmologyDuke UniversityDurhamUSA
  2. 2.The Duke Center for Macular Diseases and Albert Eye Research Institute, Duke University Eye CenterDurhamUSA

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