Fundus Autofluorescence Imaging in Age-Related Macular Degeneration and Geographic Atrophy

  • Srilaxmi Bearelly
  • Scott W. Cousins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


The traditional method for documenting and quantifying geographic atrophy (GA) is color photography. This method has been shown to be reproducible in several clinical trials, including the Age-related Eye Disease Study (AREDS) and the natural progression of GA studies by Sunness et al. (AREDS No. 6, Am J Ophthalmol 132(5):668–681, 2001; Sunness et al., Invest Ophthalmol Vis Sci 40(8):1761–1769, 1999). Nevertheless, it can be difficult to distinguish between dead/nonfunctioning retinal pigment epithelium (RPE), living but depigmented RPE (RPE often release melanin granules upon injury), and yellowish coloration caused by large drusen or calcified regressed drusen. Two imaging technologies that seem promising are fundus autofluorescence (FAF) and spectral domain (high resolution) optical coherence tomography (SDOCT). Here we provide an overview of FAF imaging in the setting of age-related macular degeneration (AMD) and GA.


Retinal Pigment Epithelium Geographic Atrophy Fundus Autofluorescence Color Fundus Photograph Color Fundus Photo 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.The Duke Center for Macular Diseases, Duke Eye CenterDurhamUSA
  2. 2.The Duke Center for Macular Diseases and Albert Eye Research InstituteDuke University Eye CenterDurhamUSA
  3. 3.Department of OphthalmologyDuke UniversityDurhamUSA

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