Prevention of Lesion Recurrence in Endovascular Devices

  • Adrienne L. Rochier
  • Bauer E. Sumpio


Although the use of autogenous bypass grafts is generally considered the optimal technique of augmenting perfusion to poorly perfused limbs, many patients do not have adequate conduit or are not at suitable risk for invasive surgery. One of the innovations over the last few decades has been the development of techniques to restore flow through endovascular methods such as angioplasty and vascular stents. Intra-arterial stent placement to treat atherosclerotic obstruction was proposed by Dotter and Judkins in 1964. The first use of percutaneously implanted stents in human arteries was the placement of the Wallstent in coronary, iliac, and femoral arteries in 1987 [1]. Shortly thereafter, favorable results in a multicenter trial with the Palmaz stent in iliac arteries were reported [2]. Stents were approved by the US Food and Drug Administration for use in iliac arteries in the United States in 1991.


Vascular Endothelial Growth Factor Intimal Hyperplasia Smooth Muscle Cell Proliferation Lesion Recurrence Neointimal Formation 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Adrienne L. Rochier
    • 1
  • Bauer E. Sumpio
    • 1
  1. 1.Department of Vascular SurgeryYale University School of MedicineNew HavenUSA

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