• Angele McGrady
  • Donald Moss


Depression is a serious disorder, affecting 12 % of adult males and 25 % of adult females in the United States, and approximately 121 million people worldwide. Depression frequently progresses to a chronic condition, often producing disability. The social, economic, and medical costs are substantial. Depression has a strong heritability, based on a polygenic transmission. Environmental factors contribute substantially to the onset, maintenance, and chronicity of depression, in the form of depressed parents, social learning, stressful life events, separation and loss, and psychological trauma. Pathways approaches to healing depression draw on nutrition, exercise, social support, imagery, psychotherapy, and a variety of mind-body and complementary therapies.


Depression Anxiety Mood Prevalence Neurobiological ­mechanisms Integrative treatment 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Angele McGrady
    • 1
  • Donald Moss
    • 2
  1. 1.Department of PsychiatryUniversity of ToledoToledoUSA
  2. 2.School of Mind-Body MedicineSaybrook UniversitySan FranciscoUSA

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