Vaccination Against Typhoid Fever: A Century of Research. End of the Beginning or Beginning of the End?



As its name implies, typhoid fever is a septicemic illness associated with alteration in consciousness (the Greek word “typhos” means “stupor”). It is cause by the Gram-negative bacillus Salmonella typhi which belongs to the enterobacteriaceae family. In its untreated form, the disease is marked by increasing fever, headache, insomnia, and general malaise. More serious complications include intestinal ­perforations and bleeding, severe alteration in consciousness, and possibly shock, which can be fatal. Similar but usually less severe cases, called paratyphoid fever, are caused by Salmonella paratyphi A, B, and C. Together, S. typhi and S. paratyphi infections are referred to as enteric fevers.


Typhoid Fever Bacillary Dysentery Uridine Diphosphate Typhoid Vaccine Paratyphoid Fever 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Unité de Pathogénie Microbienne MoléculaireINSERM U389, Institut PasteurParisFrance

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