BOLD fMRI pp 71-92 | Cite as

Challenges in fMRI and Its Limitations

  • R. Todd Constable


This chapter will explore some of the challenges of functional magnetic resonance imaging (fMRI), particularly the constraints encountered in terms of spatial and temporal resolution, as well as the factors that limit the ability of MRI to detect functional activation. These issues of sensitivity and resolution are intimately related and not easily separable; for example, increasing spatial resolution usually can only be achieved at the expense of temporal resolution and sensitivity loss. In addition to examining the factors limiting the sensitivity and resolution of fMRI, this chapter will explore some of the trade-offs involved in optimizing one or more of these variables.


Cerebral Blood Flow Cerebral Blood Volume Arterial Spin Label Echo Planar Imaging fMRI Experiment 
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Copyright information

© Springer New York 2010

Authors and Affiliations

  • R. Todd Constable
    • 1
  1. 1.Department of Diagnostic Radiology, Neurosurgery, and Biomedical Engineering; and the Magnetic Resonance Research CenterYale University School of MedicineNew HavenUSA

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