Temporal and Spatial Clustering of Bacterial Genotypes

  • Blanca Gallego


Genotypic characterization of bacterial isolates provides valuable information for epidemiological surveillance and microbial population biology. In particular, the ability to discern clonal relatedness among isolates can be used to identify links and sites of transmission, some of which are not easily traced using conventional contact investigation. The spatial and temporal clustering of isolates that share the same or closely related genotypes can add further value to the use of molecular fingerprinting in the detection and management of infectious disease outbreaks. This chapter reviews and discusses the use of both spatio-temporal clustering and bacterial genotypes in public health biosurveillance and includes examples of temporal and spatial clustering of bacterial genotypes that allow for the integration of bacterial genotyping into public health decision making.


Spatial Cluster Exponentially Weighted Move Average Statistical Process Control Public Health Action Outbreak Detection 



The author acknowledges substantial contributions from Qinning Wang, Gwendolyn L Gilbert, Vitali Sintchenko and Peter Howard of the Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Sydney West Area Health Service and The University of Sydney. This work was supported by the Australian Research Council.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Blanca Gallego
    • 1
  1. 1.Centre for Health InformaticsUniversity of New South WalesSydneyAustralia

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