Photodynamic Therapy for the Treatment of Sebaceous Gland Hyperplasia

  • Michael H. Gold


Sebaceous gland hyperplasia (SGH) is seen routinely in both traditional ­medical and in surgical or esthetic-based dermatologic practices. Treatment options vary and will be reviewed herein; ALA-PDT has proven efficacious in the treatment of SGH.


Sebaceous Gland Light Therapy Intense Pulse Light Oral Isotretinoin Drug Incubation 
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  1. 1.
    Habif TP. Clinical dermatology: a color guide to ­diagnosis and therapy. 4th ed. New York: Mosby; 2004.Google Scholar
  2. 2.
    Hogan D, Jones RW, Mason SH. Sebaceous hyperplasia. Available at: Accessed 14 April 2006.
  3. 3.
    Montagna W. An introduction to sebaceous glands. J Invest Dermatol. 1974;62(3):120–3.PubMedCrossRefGoogle Scholar
  4. 4.
    Braun-Falco O, Thianprasit M. On circumscribed senile sebaceous gland hyperplasia. Arch Klin Exp Dermatol. 1965;221:207–31.PubMedCrossRefGoogle Scholar
  5. 5.
    Plewig G, Kligman AM. Proliferative activity of the sebaceous glands of the aged. J Invest Dermatol. 1978;70(6):314–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Luderschmidt C, Plewig G. Circumscribed sebaceous gland hyperplasia: autoradiographic and histoplanimetric studies. J Invest Dermatol. 1978;70(4):207–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Bencini PL, Montagnino G, Sala F, De Vecchi A, Crosti C, Tarantino A. Cutaneous lesions in 67 cyclosporin-treated renal transplant recipients. Dermatologica. 1986;172(1):24–30.PubMedCrossRefGoogle Scholar
  8. 8.
    Walther T, Hohenleutner U, Landthaler M. Sebaceous gland hyperplasia as a side effect of cyclosporin A. Treatment with the CO2 laser. Dtsch Med Wochenschr. 1998;123(25–26):798–800.PubMedCrossRefGoogle Scholar
  9. 9.
    Grimalt R, Ferrando J, Mascaro JM. Premature familial sebaceous hyperplasia: successful response to oral isotretinoin in three patients. J Am Acad Dermatol. 1997;37(6):996–8.PubMedCrossRefGoogle Scholar
  10. 10.
    Lynch HT, Fusaro RM, Roberts L, Voorhees GJ, Lynch JF. Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome. Br J Dermatol. 1985;113(3):295–301.PubMedCrossRefGoogle Scholar
  11. 11.
    Schwartz RA, Goldberg DJ, Mahmood F, DeJager RL, Lambert WC, Najem AZ, et al. The Muir-Torre syndrome: a disease of sebaceous and colonic neoplasms. Dermatologica. 1989;178(1):23–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Matsui Y, Nishii Y, Maeda M, Okada N, Yoshikawa K. Pachydermoperiostosis–report of a case and review of 121 Japanese cases. Nippon Hifuka Gakkai Zasshi. 1991;101(4):461–7.PubMedGoogle Scholar
  13. 13.
    Jansen T, Brandl G, Bandmann M, Meurer M. Pachyder­moperiostosis. Hautarzt. 1995;46(6):429–35.PubMedCrossRefGoogle Scholar
  14. 14.
    Orge C, Bonsmann G, Hamm H. Multiple sebaceous gland hyperplasias in X chromosome hypohidrotic ectodermal dysplasia. Hautarzt. 1991;42(10):645–7.PubMedGoogle Scholar
  15. 15.
    Dupre A, Bonafé JL, Lamon R. Functional familial sebaceous hyperplasia of the face. Reverse of the Cunliffe acne-free naevus? Its inclusion among naevoid sebaceous receptor diseases. Clin Exp Dermatol. 1980;5(2):203–7.PubMedCrossRefGoogle Scholar
  16. 16.
    De Villez RL, Roberts LC. Premature sebaceous gland hyperplasia. J Am Acad Dermatol. 1982;6(5):933–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Czarnecki DB, Dorevitch AP. Giant senile sebaceous hyperplasia. Arch Dermatol. 1986;122(10):1101.PubMedCrossRefGoogle Scholar
  18. 18.
    Uchiyama N, Yamaji K, Shindo Y. Giant solitary sebaceous gland hyperplasia on the frontal region. Dermatologica. 1990;181(1):60–1.PubMedCrossRefGoogle Scholar
  19. 19.
    Aghassi D, Anderson RR, González S. Time-sequence histologic imaging of laser-treated cherry angiomas with in vivo confocal microscopy. J Am Acad Dermatol. 2000;43(1 Pt 1):37–41.PubMedCrossRefGoogle Scholar
  20. 20.
    Horio T, Horio O, Miyauchi-Hashimoto H, Ohnuki M, Isei T. Photodynamic therapy of sebaceous hyperplasia with topical 5-aminolaevulinic acid and slide projector. Br J Dermatol. 2003;148(6):1274–6.PubMedCrossRefGoogle Scholar
  21. 21.
    Liu HN, Perry HO. Identifying a common–and benign–geriatric skin lesion. Geriatrics 1986;41(7):71–3, 76.Google Scholar
  22. 22.
    Schönermark MP, Schmidt C, Raulin C. Treatment of sebaceous gland hyperplasia with the pulsed dye laser. Lasers Surg Med. 1997;21(4):313–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Blanchet-Bardon C, Servant JM, Le Tuan B, Puissant A. Acquired sebaceous hyperplasia of cutis verticis gyrata type sensitive to 13-cis-retinoid. Ann Dermatol Venereol. 1982;109(9):749–50.PubMedGoogle Scholar
  24. 24.
    Grekin RC, Ellis CN. Isotretinoin for the treatment of sebaceous hyperplasia. Cutis. 1984;34(1):90–2.PubMedGoogle Scholar
  25. 25.
    Burton CS, Sawchuk WS. Premature sebaceous gland hyperplasia: successful treatment with isotretinoin. J Am Acad Dermatol. 1985;12(1 Pt 2):182–4.PubMedCrossRefGoogle Scholar
  26. 26.
    Wheeland RG, Wiley MD. Q-tip cryosurgery for the treatment of senile sebaceous hyperplasia. J Dermatol Surg Oncol. 1987;13(7):729–30.PubMedGoogle Scholar
  27. 27.
    Rosian R, Goslen JB, Brodell RT. The treatment of benign sebaceous hyperplasia with the topical application of bichloracetic acid. J Dermatol Surg Oncol. 1991;17(11):876–9.PubMedGoogle Scholar
  28. 28.
    Bader RS, Scarborough DA. Surgical pearl: intralesional electrodesiccation of sebaceous hyperplasia. J Am Acad Dermatol. 2000;42(1 Pt 1):127–8.PubMedCrossRefGoogle Scholar
  29. 29.
    Landthaler M, Haina D, Waidelich W, Braun-Falco O. A three-year experience with the argon laser in dermatotherapy. J Dermatol Surg Oncol. 1984;10(6):456–61.PubMedGoogle Scholar
  30. 30.
    Marsili M, Cockerell CJ, Lyde CB. Hemangioma-associated rhinophyma. Report of a case with ­successful treatment using carbon dioxide laser ­surgery. J Dermatol Surg Oncol. 1993;19(3):206–12.PubMedGoogle Scholar
  31. 31.
    González S, White WM, Rajadhyaksha M, Anderson RR, González E. Confocal imaging of sebaceous gland hyperplasia in vivo to assess efficacy and mechanism of pulsed dye laser treatment. Lasers Surg Med. 1999;25(1):8–12.PubMedCrossRefGoogle Scholar
  32. 32.
    No D, McClaren M, Chotzen V, Kilmer SL. Sebaceous hyperplasia treated with a 1450-nm diode laser. Dermatol Surg. 2004;30(3):382–4.PubMedCrossRefGoogle Scholar
  33. 33.
    Alster TS, Tanzi EL. Photodynamic therapy with ­topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia. J Drugs Dermatol. 2003;2(5):501–4.PubMedGoogle Scholar
  34. 34.
    Goldman MP. Using 5-aminolevulinic acid to treat acne and sebaceous hyperplasia. Cosmetic Dermatol. 2003;16:57–8.Google Scholar
  35. 35.
    Richey DF, Hopson B. Treatment of sebaceous hyperplasia by photodynamic therapy. Cosmetic Dermatol. 2004;17:525–9.Google Scholar
  36. 36.
    Gold MH, Bradshaw VL, Boring MM, Bridges TM, Biron JA, Lewis TL. Treatment of sebaceous gland hyperplasia by photodynamic therapy with 5-aminolevulinic acid and a blue light source or intense pulsed light source. J Drugs Dermatol. 2004;3(6):S5–8.Google Scholar
  37. 37.
    Nestor MS, Gold MH, Kauvar AN, Taub AF, Geronemus RG, Ritvo EC. The use of photodynamic therapy in dermatology: results of a consensus conference. J Drugs Dermatol. 2006;5(2):140–54.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gold Skin Care Center, Tennessee Clinical Research CenterNashvilleUSA
  2. 2.Department of DermatologyVanderbilt University School of Medicine and Vanderbilt University School of NursingNashvilleUSA

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