Ricin: A Possible, Noninfectious Biological Weapon

  • Maor Maman
  • Yoav Yehezkelli
Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC)


On September 7, 1978, 49-year-old Bulgarian exile named Georgi Markov was hit by an umbrella's tip while waiting in a bus station in London. The next day, he was admitted to a hospital in a severe condition, which rapidly deteriorated, terminating in his death 4 days later. A tiny pellet was removed from his thigh in autopsy. Based on the clinical course and on the pellet dimensions, it was concluded that Markov was assassinated using the poison ricin (Crompton and Gall, 1980; Franz and Jaax, 1997).


Castor Bean Personal Protective Equipment Dermal Exposure Biological Weapon Inhalational Anthrax 
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We would like to express our sincere appreciation to Mrs. Sarah Efrati for her tremendous effort and assistance in information collection, and for being available around the clock.


  1. Alibek, K. (1999). Biohazard. New York, Random House, IncGoogle Scholar
  2. CDC. (2000). Biological and chemical terrorism: strategic plan for preparedness and response rec ommendations of the CDC Strategic Planning Workgroup. MMWR49(RR-4):1–14.Google Scholar
  3. Centers for Disease Control and Prevention. (2003). Laboratory testing for ricin in environmental samples—fact sheet. Available at:
  4. Challoner, K.R., and McCarron, M.M. (1990). Castor bean intoxication. Ann. Emerg. Med.19:1177–1183.PubMedCrossRefGoogle Scholar
  5. Christopher, G.W., Cieslak, T.J., Palvin, J.A., and Eitzen, E.M. (1997). Biological warfare. A historical perspective. J.A.M.A. 278:412–417.PubMedCrossRefGoogle Scholar
  6. Crompton, R., and Gall, D. (1980). Georgi Markov—death in a pellet. Medico Legal J. 48(2):51–62.Google Scholar
  7. Eitzen, E.M., and Takafuji, E.T. (1997). Historical overview of biological warfare. In: Sidell, F.R., Takafuji, E.T., and Franz, D.R. (eds.), Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. TMM Publications, Washington, D.C.Google Scholar
  8. Ellenhorn, M.J. (1997). Plants—mycotoxins—mushrooms. In: Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. Baltimore, Williams & Wilkins, pp. 1847– 1849.Google Scholar
  9. Fodstad, O., Kvalheim, G., Godal, A., Lotsberg, J., Aamdal, S., Host, H., and Pihl, A. (1984). Phase I study of plant protein ricin. Cancer Res. 44:862–865.PubMedGoogle Scholar
  10. Franz, D.R., and Jaax, N.K. (1997). Ricin toxin. In: Sidell, F.R., Takafuji, E.T., and Franz, D.R. (eds.), Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. TMM Publications, Washington, D.C.Google Scholar
  11. Frigerio, L., and Roberts, L.M. (1998). The enemy within: ricin and plant cells. J. Exp. Botany49(326):1473–1480.Google Scholar
  12. Hampton, T. (2004). Ricin vaccine developed. JAMA292:1419-a.Google Scholar
  13. Hostetler, M.A. (2003). Toxicity, plants—castor bean and jequirity bean. Available at:
  14. Kaku, H. (1998). Ricin related protein family. Available at:
  15. Kende, M., Yan, C., Hewetson, J., Frick, M.A., Rill, W.L., and Tammariello, R. (2002). Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge. Vaccine20(11–12):1681–1691.PubMedCrossRefGoogle Scholar
  16. Koppel, A., MacVicar, S., Schuster, H., and Moniquet, C. (2003). Deadly ricin at Paris rail station. Available at:
  17. Kortepeter, M.G., Christopher, G., Cieslak, T., Culpepper, R., Darling, R., Palvin, J., Rowe, J., McKee, K., and Eitzen, E. (2001). USAMRIID's Medical Management of Biological Casualties Handbook, 4th ed. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, pp. 130–137.Google Scholar
  18. Kortepeter, M.G., and Parker, G.W. (1999). Potential biological weapons threats. Emerg. Infect. Dis.5:523–527.PubMedCrossRefGoogle Scholar
  19. Kreitman, R.J. (1999). Immunotoxins in cancer therapy. Curr. Opin. Immunol. 11:570–578.PubMedCrossRefGoogle Scholar
  20. Kreitman, R.J. (2001). Toxin-labeled monoclonal antibodies. Curr. Pharm. Biotechnol. 2:313–325.PubMedCrossRefGoogle Scholar
  21. Lord, J.M., Roberts, L.M., and Robertus J.D. (1994). Ricin: structure, mode of action, and some current applications. FASEB J.8:201–208.PubMedGoogle Scholar
  22. Maman, M., Sagi, R., Moseri, R., and Yehezkelli, Y. (2003). Ricin—a potent plant toxin. In: Shoenfeld, Y., and Shemer, J. (eds.), Terror and Medicine. Pabst Science Publishers, Berlin.Google Scholar
  23. Mayor, S. (2003). UK doctors warned after a ricin poison was found in police raid. Br. Med. J.326:126.CrossRefGoogle Scholar
  24. Mirarchi, F.L., and Allswede, M. (2003). CBRNE—ricin. Available at:
  25. Oeltmann, T.N., and Frankel, A.E. (1991). Advances in immunotoxins. FASEB J.5(10):2334–2337.PubMedGoogle Scholar
  26. Old Testament.(1982). Jonah 4:6–9. Copyright by Y. Orestein, “Yavne” Publishing House, Ltd., Tel-Aviv.Google Scholar
  27. Olsnes, S., and Kozlov, J.V. (2001). Ricin. Toxicon39:1723–1728.PubMedCrossRefGoogle Scholar
  28. Olsnes, S., and Pihl, A. (1976). Abrin, ricin and their associated agglutinins. In Cuatrecasas, P. (eds.), Receptors and Recognition. Series B. The Specificity and Action of Animal, Bacterial and Plant Toxins. Chapman and Hall, London, pp. 129–173.Google Scholar
  29. Rauber, A., and Heard, J. (1985). Castor bean toxicity re-examined: a new prospective. Vet. Hum. Toxicol.27:498–502.PubMedGoogle Scholar
  30. Sandvig, K., and Van Deurs, B. (2000). Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives. EMBO J.19:5943–5950.PubMedCrossRefGoogle Scholar
  31. Sandvig, K., and Van Deurs, B. (2002). Transport of protein toxins into cells: pathways used by ricin, cholera toxin and shiga toxin. FEBS Lett. 529(1):49–53.PubMedCrossRefGoogle Scholar
  32. Shyu, H.F., Chaio, D.J., Liu, H.W., and Tang, S.S. (2002). Monoclonal antibody-based enzyme immunoassay for detection ricin. Hybrid Hybridomics21:69–73.PubMedCrossRefGoogle Scholar
  33. Smallshaw, J.E., Firan, A., Fulmer, J.R., Ruback, S.L, Ghetie, V., and Vitetta, E.S. (2002). A novel recombinant vaccine which protects mice against ricin intoxication. Vaccine20:3422–3427.PubMedCrossRefGoogle Scholar
  34. Wedin, G.P., Neal, J.S., Everson, G.W., and Krenzelok, E.P. (1986). Castor bean poisoning. Am. J. Emerg. Med.4(3):259–261.PubMedCrossRefGoogle Scholar
  35. Weissmann-Brenner, A., Brenner, B., Kats, L., and Hourvitz, A. (2002). Ricin—from a Bulgarian umbrella to an optional treatment of cancer. Harefuah141:153–156. [Hebrew].PubMedGoogle Scholar
  36. Yan, C., Rill, W.L., Malli, R., Hewetson, J., Naseem, H., Tammariello, R., and Kende, M. (1996). Intranasal stimulation of long lasting immunity against aerosol ricin challenge with ricin toxoid vaccine encapsulated in polymer microspheres. Vaccine14:1031–1038.PubMedCrossRefGoogle Scholar
  37. Zilinskas, R.A. (1997). Iraq's biological weapons: the past as future? J.A.M.A.278:418–424.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maor Maman
    • 1
  • Yoav Yehezkelli
    • 1
  1. 1.Israel Defense Forces Medical Corps HeadquartersIsrael

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