Genetically Encoded Fluorescent and Bioluminescent Probes for Illuminating Cellular Signaling Pathways

  • Yoshio Umezawa
Part of the Reviews in Fluorescence 2008 book series (RFLU, volume 2008)


The intracellular signaling can be monitored in vivo in living cells by genetically encoded intracellular fluorescent and bioluminescent probes or indicators, which include second messengers, protein phosphorylation, protein–protein interactions, and protein localizations in organelles. These probes are of general use not only for fundamental biological studies but also for assay and screening of possible pharmaceutical or toxic chemicals that inhibit or facilitate cellular signaling pathways.


Nitric Oxide Fluorescence Resonance Energy Transfer Yellow Fluorescent Protein Cellular Signaling Pathway Fluorescent Indicator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of ChemistrySchool of Science, The University of Tokyo HongoTokyoJapan

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