Multicolor Imaging with Fluorescent Proteins in Mice

In Vivo Imaging with Fluorescent Proteins
  • Robert M. Hoffman
Part of the Reviews in Fluorescence 2008 book series (RFLU, volume 2008)


The high extinction coefficients, quantum yields, and unique spectral properties of fluorescent proteins are optimal for imaging in live animals in real time. The important aspects of cancer in living animals, including tumor cell mobility, invasion, metastasis, and angiogenesis, can be imaged. Fluorescent proteins enable whole-body imaging of tumors on internal organs. Proteins which are spectrally distinct have allowed the color coding of cancer cells growing in vivo with distinction of different cell types, including host from tumor, with single-cell resolution. Individual cells can be multicolored to study nuclear–cytoplasmic dynamics in the living animal.


Nude Mouse Fluorescent Protein Lewis Lung Carcinoma Vascular Endothelial Growth Factor Promoter Syngeneic Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.AntiCancer, IncSan DiegoUSA
  2. 2.Department of SurgeryUniversity of CaliforniaSan DiegoUSA

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