GABAergic Transmission and Neuronal Network Events During Hippocampal Development



The immature hippocampus generates spontaneous network events which are known as giant depolarizing potentials (GDPs) in experiments carried out in vitro. GDPs are generally thought to be driven by the interneuronal network, because they can be recorded from hippocampal slices during the early neonatal period when GABAA receptor-mediated responses are depolarizing. Recent work indicates, however, that GDPs are paced by glutamatergic neurons, and that the functionally excitatory action of GABA during early development is facilitatory but not instructive. In experiments done in vivo, sharp positive waves (SPWs) can be detected in both neonate and adult rodents. Taken together, the available evidence suggests that GDPs are the in vitro counterparts of SPWs in the immature hippocampus.


GABAA Receptor Network Event GABAergic Transmission GABAA Receptor Antagonist Intrinsic Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors’ original research work has been supported by the Academy of Finland, the Jane and Aatos Erkko Foundation and the Sigrid Jusélius Foundation. The authors thank Drs. Roustem Khazipov, Liset Menendez de la Prida, Michael O’Donovan, Eva Ruusuvuori, and Else Tolner for constructive comments on an early draft of the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Clinical NeurophysiologyOulu University HospitalOuluFinland
  2. 2.Department of Biosciences and Neuroscience CenterUniversity of HelsinkiHelsinkiFinland

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