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Oxygen Transport to Tissue XXXI pp 531–536Cite as

Effects of Oral Single-Dose Administration of Sarpogrelate Hydrochloride on Saturation O2 of Calf Muscle During Plantar Flexion Exercise

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 662))

Abstract

To investigate the effects of a 100-mg oral single-dose administration of sarpogrelate hydrochloride (SH) on saturation O2 (StO2) of calf muscle in healthy subjects experiencing simulated peripheral arterial disease (0.6 ankle brachial pressure index). Ten subjects performed three kinds of plantar flexion exercises at a work rate of 50% of maximal volunteer contraction for 4 min by using cuff occlusion ischemia,. Subjects performed a control test (C) without ischemia and SH, an ischemia test (I) without SH, and an I + SH test with ischemia. StO2, blood pressures (BP), and heart rate (HR) were measured through all experiments. At the end of the exercise, the decrease in StO2 from baseline in the C and I + SH tests was significantly less than that in the I test (p < 0.05, respectively). However, there were no significant differences in mean BP or HR in any of the exercise conditions. These results indicated that an oral single-dose administration of SH might improve peripheral circulation independent of any changes in BP and HR.

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References

  1. Bauer TA, Brass EP, Barstow TJ, Hiatt WR (2007) Skeletal muscle StO2 kinetics are slowed during low work rate calf muscle in peripheral arterial disease. Eur J Appl Phyisol 100: 143–151.

    Article  Google Scholar 

  2. Hara H, Osakabe M, Kitajima A, Tamamo Y, Kikumoto R (1991) MCI-9042, a new antiplatelet agent is a selective S2-serotonergic receptor antagonist. Thromb Haemost 65(4): 415–420.

    PubMed  CAS  Google Scholar 

  3. Isogai Y, Yokose T, Ikemoto T, Maeda T, Akiyama M, Hara H, Kitajima A, Izawa O (1991) Phase- 1 Study of sarpogrelate hydrochloride (MCI-9042) – single and repeated oral administration study. J Clin Therap Med 7 (6): 1177–1192.

    Google Scholar 

  4. Kawaguchi K, Tabusadani M, Sekikawa K, Hayashi Y, Onari K (2001) Do the kinetics of peripheral muscle oxygenation reflect systemic oxygen intake? Eur J Appl Physiol 84: 158–161.

    Article  PubMed  CAS  Google Scholar 

  5. Komiyama T, Shigematus H, Yasuhara H, Muto T (2000) Near-infrared spectroscopy grades the severity of the intermittent claudication in diabetics more accurately than ankle pressure measurement. Br J Surg 87(4): 459–466.

    Article  PubMed  CAS  Google Scholar 

  6. Matsubara J, Shiiya N, Ishida A, Miyata T, Shigematsu H, Obitsu Y, Shindo T, Hida K, Ohta T, Ando M, Nishibe T, Kawasaki T, Yasugi T, Onohara T (2007) Current status of medication therapy for arteriosclerosis obliterans (ASO) in University Hospital in Japan. J Jpn Coll Angiol 47: 153–162.

    Google Scholar 

  7. McCully K, Landsberg L, Suarez M, Hofman M, Posner JD (1997) Identification of peripheral vascular disease in elderly subjects using optical spectroscopy. J Gerontology 52A: B15–B165.

    Google Scholar 

  8. Miyazaki M, Higashi Y, Goto C, Chayama K, Yoshizumi M, Sanada H, Orihashi K, Sueda T (2007) Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease. J Cardiovasc Pharamacol 49(4): 221–227.

    Article  CAS  Google Scholar 

  9. Tsuchihashi H, Yagi N, Kimura M, Shirota K, Kinami J, Ngatomo T (1991) Binding characteristics of 3H ketanserin for serotonin-2 receptor in the rabbit platelet. J Pharmacobiodyn 14(8): 461–466.

    PubMed  CAS  Google Scholar 

  10. Vanhoutte PM, Houston DS (1985) Platelets, endothelium, and vasospasm. Circulation 72(4): 728–734.

    PubMed  CAS  Google Scholar 

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Acknowledgments

This study was supported by Tanabe-Mitsubishi Pharmaceutical Company.

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Authors and Affiliations

  1. Department of Human Care Studies, Hokkaido University of Education, Sapporo, Japan

    Masahiro Horiuchi

  2. Department of Wellness Planning, Hokkaido University of Education, Sapporo, Japan

    Koichi Okita, Shingo Takada & Masashi Omokawa

  3. Department of Bio-System Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, 992-0038, Japan

    Tadashi Suga

  4. Department of Sports Education, Hokkaido University of Education, Sapporo, Japan

    Noriteru Morita

  5. Department of Cardiovascular Medicine, Hokkaido University of Education, Sapporo, Japan

    Kagami Hirabayashi, Takashi Yokota, Shintaro Kinugawa & Hiroyuki Tsutsui

Authors
  1. Masahiro Horiuchi
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  2. Koichi Okita
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  3. Shingo Takada
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  4. Masashi Omokawa
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  5. Tadashi Suga
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  6. Noriteru Morita
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  7. Kagami Hirabayashi
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  8. Takashi Yokota
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  9. Shintaro Kinugawa
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  10. Hiroyuki Tsutsui
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Corresponding author

Correspondence to Masahiro Horiuchi .

Editor information

Editors and Affiliations

  1. School of Medicine, Yamagata University, Yamagata, 990-9585, Japan

    Eiji Takahashi

  2. Westminster Rd 2773, Ellicott City, 21043, U.S.A.

    Duane F. Bruley

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Horiuchi, M. et al. (2010). Effects of Oral Single-Dose Administration of Sarpogrelate Hydrochloride on Saturation O2 of Calf Muscle During Plantar Flexion Exercise. In: Takahashi, E., Bruley, D. (eds) Oxygen Transport to Tissue XXXI. Advances in Experimental Medicine and Biology, vol 662. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1241-1_77

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