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Effects of Oral Single-Dose Administration of Sarpogrelate Hydrochloride on Saturation O2 of Calf Muscle During Plantar Flexion Exercise

  • Masahiro Horiuchi
  • Koichi Okita
  • Shingo Takada
  • Masashi Omokawa
  • Tadashi Suga
  • Noriteru Morita
  • Kagami Hirabayashi
  • Takashi Yokota
  • Shintaro Kinugawa
  • Hiroyuki Tsutsui
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)

Abstract

To investigate the effects of a 100-mg oral single-dose administration of sarpogrelate hydrochloride (SH) on saturation O2 (StO2) of calf muscle in healthy subjects experiencing simulated peripheral arterial disease (0.6 ankle brachial pressure index). Ten subjects performed three kinds of plantar flexion exercises at a work rate of 50% of maximal volunteer contraction for 4 min by using cuff occlusion ischemia,. Subjects performed a control test (C) without ischemia and SH, an ischemia test (I) without SH, and an I + SH test with ischemia. StO2, blood pressures (BP), and heart rate (HR) were measured through all experiments. At the end of the exercise, the decrease in StO2 from baseline in the C and I + SH tests was significantly less than that in the I test (p < 0.05, respectively). However, there were no significant differences in mean BP or HR in any of the exercise conditions. These results indicated that an oral single-dose administration of SH might improve peripheral circulation independent of any changes in BP and HR.

Keywords

Peripheral Arterial Disease Calf Muscle Blood Flow Restriction Ankle Brachial Pressure Index Peripheral Arterial Disease Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by Tanabe-Mitsubishi Pharmaceutical Company.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Masahiro Horiuchi
    • 1
  • Koichi Okita
    • 2
  • Shingo Takada
    • 2
  • Masashi Omokawa
    • 2
  • Tadashi Suga
    • 3
  • Noriteru Morita
    • 4
  • Kagami Hirabayashi
    • 5
  • Takashi Yokota
    • 5
  • Shintaro Kinugawa
    • 5
  • Hiroyuki Tsutsui
    • 5
  1. 1.Department of Human Care StudiesHokkaido University of EducationSapporoJapan
  2. 2.Department of Wellness PlanningHokkaido University of EducationSapporoJapan
  3. 3.Department of Bio-System EngineeringGraduate School of Science and Engineering, Yamagata UniversityYonezawaJapan
  4. 4.Department of Sports EducationHokkaido University of EducationSapporoJapan
  5. 5.Department of Cardiovascular MedicineHokkaido University of EducationSapporoJapan

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