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Effects of Revascularisation on Evoked Cerebral Blood Oxygenation Responses in Stroke Patients

  • Shin Nakamura
  • Kaoru Sakatani
  • Tsuneo Kano
  • Tetsuya Hoshino
  • Norio Fujiwara
  • Yoshihiro Murata
  • Yoichi Katayama
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)

Abstract

We demonstrated that ischemic strokes exhibit an increase of deoxyhemoglobin during activation. We evaluated the effect of revascu-larization on the abnormal evoked cerebral blood oxygenation (CBO) re-sponses in these patients, employing near-infrared spectroscopy (NIRS). We selected five patients who exhibited an increase of deoxyhemoglobin associated with increases of oxyhemoglobin and total hemoglobin during activation for this study. These patients showed marked reductions of base-line regional cerebral blood flow and cerebrovascular reserve capacity, which were improved 1 week after revascularization. Postoperative NIRS demonstrated that the increase of deoxyhemoglobin during activa-tion was not observed after revascularization. This preliminary study demonstrated that the abnormal evoked-CBO response in ischemic stroke patients could be improved by revascularization.

Keywords

Stroke Patient Ischemic Stroke Patient Lesion Side Neurovascular Coupling Relative Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shin Nakamura
    • 1
  • Kaoru Sakatani
    • 2
    • 3
  • Tsuneo Kano
    • 4
  • Tetsuya Hoshino
    • 1
  • Norio Fujiwara
    • 5
  • Yoshihiro Murata
    • 6
  • Yoichi Katayama
    • 4
    • 3
  1. 1.Department of NeurosurgeryNihon University School of MedicineTokyoJapan
  2. 2.Division of Optical Brain Engineering, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  3. 3.Division of Applied System Neuroscience, Department of Advanced Medical ScienceNihon University School of MedicineTokyoJapan
  4. 4.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  5. 5.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  6. 6.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan

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