Effects of Revascularisation on Evoked Cerebral Blood Oxygenation Responses in Stroke Patients

  • Shin Nakamura
  • Kaoru Sakatani
  • Tsuneo Kano
  • Tetsuya Hoshino
  • Norio Fujiwara
  • Yoshihiro Murata
  • Yoichi Katayama
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)


We demonstrated that ischemic strokes exhibit an increase of deoxyhemoglobin during activation. We evaluated the effect of revascu-larization on the abnormal evoked cerebral blood oxygenation (CBO) re-sponses in these patients, employing near-infrared spectroscopy (NIRS). We selected five patients who exhibited an increase of deoxyhemoglobin associated with increases of oxyhemoglobin and total hemoglobin during activation for this study. These patients showed marked reductions of base-line regional cerebral blood flow and cerebrovascular reserve capacity, which were improved 1 week after revascularization. Postoperative NIRS demonstrated that the increase of deoxyhemoglobin during activa-tion was not observed after revascularization. This preliminary study demonstrated that the abnormal evoked-CBO response in ischemic stroke patients could be improved by revascularization.


Stroke Patient Ischemic Stroke Patient Lesion Side Neurovascular Coupling Relative Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Cramer SC, Nelles G, Benson RR et al. (1997) A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 28:2518–2527PubMedGoogle Scholar
  2. 2.
    Cao Y, D’Olhaberriague L, Vikingstad EM et al. (1998) Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29:112–122PubMedGoogle Scholar
  3. 3.
    Kato H, Izumiyama M, Koizumi H et al. (2002) Near-infrared spectroscopic topography as a tool to monitor motor reorganization after hemiparetic stroke: A comparison with functional MRI. Stroke 33:2032–2036PubMedCrossRefGoogle Scholar
  4. 4.
    Pineiro R, Pendlebury S, Johansen-Berg H et al. (2002) Altered hemodynamic responses in patients after subcortical stroke measured by functional MRI. Stroke 33:103–109PubMedCrossRefGoogle Scholar
  5. 5.
    Röther J, Knab R, Hamzei F et al. (2002) Negative dip in BOLD fMRI is caused by blood flow-oxygen consumption uncoupling in humans. NeuroImage 15:98–102PubMedCrossRefGoogle Scholar
  6. 6.
    D'Esposito M, Deouell LY, Gazzaley A (2003) Alterations in the BOLD fMRI signal with aging and disease: A challenge for neuroimaging. Nature Rev Neurosci 4:863–872CrossRefGoogle Scholar
  7. 7.
    Hamzei F, Knab R, Weiller C et al. (2003) The influence of extra- and intracranial artery disease on the BOLD signal in FMRI. NeuroImage 20:1393–1399PubMedCrossRefGoogle Scholar
  8. 8.
    Rossini PM, Altamura C, Ferretti A et al. (2004) Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127:99–110PubMedCrossRefGoogle Scholar
  9. 9.
    Binkofski F, Seitz RJ (2004) Modulation of the BOLD-response in early recovery from sensorimotor stroke. Neurology 63:1223–1229PubMedGoogle Scholar
  10. 10.
    Krainik A, Hund-Georgiadis M, Zysset S et al. (2005) Regional impairment of cerebrovascular reactivity and BOLD signal in adults after stroke. Stroke 36:1146–1152PubMedCrossRefGoogle Scholar
  11. 11.
    Ogawa S, Lee TM, Kay AR et al. (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:9868–9872PubMedCrossRefGoogle Scholar
  12. 12.
    Murata Y, Sakatani K, Hoshino T et al. (2006) Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast functional MRI in stroke patients. Stroke 37:2514–2520PubMedCrossRefGoogle Scholar
  13. 13.
    Sakatani K, Murata Y, Fujiwara N et al. (2007) Comparison of blood-oxygen-level–dependent functional magnetic resonance imaging and near-infrared spectroscopy recording during functional brain activation in patients with stroke and brain tumors. J Biomed Optics 12:062110CrossRefGoogle Scholar
  14. 14.
    Jöbsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198:1264–1267PubMedCrossRefGoogle Scholar
  15. 15.
    Hoshino T, Sakatani K, Katayama Y et al. (2005) Application of multi-channel near infrared spectroscopic topography to physiological monitoring of the cortex during cortical mapping: Technical case report. Surg Neurol 64:272–275PubMedCrossRefGoogle Scholar
  16. 16.
    Hoshino T, Katayama Y, Sakatani K et al. (2006) Intraoperative monitoring of cerebral blood oxygenation and hemodynamics during EC-IC bypass surgery by a newly developed visual light spectroscopy system. Surg Neurol 65:569–576PubMedCrossRefGoogle Scholar
  17. 17.
    Anderson DE, McLane MP, Reichman OH et al. (1992) Improved cerebral blood flow and CO2 reactivity after microvascular anastomosis in patients at high risk for recurrent stroke. Neurosurgery 31:26–33PubMedCrossRefGoogle Scholar
  18. 18.
    Gibbs JM, Wise RJ, Thomas DJ et al. (1987) Cerebral hemodynamic changes after extracranial-intracranial bypass surgery. J Neurol Neurosurg Psychiatry 50:140–150PubMedCrossRefGoogle Scholar
  19. 19.
    Powers WJ, Martin WR, Herscovitch P et al. (1984) Extracranial-intracranial bypass surgery: hemodynamic and metabolic effects. Neurology 34:1168–1174PubMedGoogle Scholar
  20. 20.
    Boxerman JI, Bandettini PA, Kwong KK et al. (1995) The intravascular contribu-tion to fMRI signal change: Monte Carlo modeling and diffusion-weighted stud-ies in vivo. Magn Reson Med 34:4–10PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shin Nakamura
    • 1
  • Kaoru Sakatani
    • 2
    • 3
  • Tsuneo Kano
    • 4
  • Tetsuya Hoshino
    • 1
  • Norio Fujiwara
    • 5
  • Yoshihiro Murata
    • 6
  • Yoichi Katayama
    • 4
    • 3
  1. 1.Department of NeurosurgeryNihon University School of MedicineTokyoJapan
  2. 2.Division of Optical Brain Engineering, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  3. 3.Division of Applied System Neuroscience, Department of Advanced Medical ScienceNihon University School of MedicineTokyoJapan
  4. 4.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  5. 5.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  6. 6.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineTokyoJapan

Personalised recommendations