We examined the usefulness of near infrared time-resolved spectroscopy (TRS) for detection of vasospasm in subarachnoid hemorrhage (SAH). We investigated seven aneurysmal SAH patients with poor clinical conditions (WFNS grade V) who underwent endovascular coil embolization. Employing TRS, we measured the oxygen saturation (SO2) and baseline hemoglobin concentrations in the cortices. Measurements of TRS and transcranial Doppler sonography (TCD) were performed repeatedly for 14 days after SAH. In four of the seven patients, the SO2 and hemoglobin concentrations measured in the brain tissue of the middle cerebral artery territory remained stable after SAH. However, in three patients, TRS revealed abrupt decreases in SO2 and total hemoglobin between 5 and 9 days after SAH. Cerebral angiography performed on the same day revealed severe vasospasms in these patients. Although TCD detected the vasospasm in two of three cases, it failed to do so in one case. TRS could detect vasospasms after SAH by evaluating the cortical blood oxygenation.
Blood Flow Velocity Contribution Ratio Transcranial Doppler Sonography Poor Clinical Condition Severe Vasospasm
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Weir B, Macdonald L, Stoodley M (1999) Etiology of cerebral vasospasm. Acta Neurochir [Suppl] 72:27–46.Google Scholar
Harders AG, Gilsbach JM (1987) Time course of blood velocity changes related to vasospasm in the circle of Willis measured by transcranial Doppler ultrasound. J Neurosurg 66:718–728.PubMedCrossRefGoogle Scholar
Creissard P, Proust F (1994) Vasospasm diagnosis: theoretical sensitivity of transcranial Doppler evaluated using 135 angiograms demonstrating vasospasm. Practical consequences. Acta Neurochir (Wien) 131:12–18.CrossRefGoogle Scholar
Lindegaard KF (1999) The role of transcranial Doppler in the management of patients with subarachnoid hemorrhage: a review. Acta Neurochir [Suppl] 72:59–71.Google Scholar
Aaslid R, Huber P, Nornes H (1984) Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg 60:37–41.PubMedCrossRefGoogle Scholar
Sloan M, Haley E, Kassell NF et al. (1989) Sensitivity and specificity of transcranial Doppler ultrasonography in the diagnosis of vasospasm following subarachnoid hemorrhage. Neurology 39:1514–1518.PubMedGoogle Scholar
Lewis DH, Newell DW, Winn HR (1997) Delayed ischemia due to cerebral vasospasm occult to transcranial Doppler. An important role of cerebral perfusion SPECT. Clin Nucl Med 22:238–240.PubMedCrossRefGoogle Scholar
Chance B, Leigh JS, Miyake H et al. (1988) Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain. Proc Natl Acad Sci USA 85:4971–4975.PubMedCrossRefGoogle Scholar
Ohmae E, Ouchi Y, Oda M et al. (2006) Cerebral hemodynamics evaluation by near-infrared time-resolved spectroscopy: correlation with simultaneous positron emission tomography measurements. NeuroImage 29:697–705.PubMedCrossRefGoogle Scholar
Hoshi Y (2003) Functional near-infrared optical imaging: utility and limitations in human brain mapping. Psychophysiology 40:511–520.PubMedCrossRefGoogle Scholar
Ijichi S, Kusaka T, Isobe K et al. (2005) Developmental changes of optical properties in neonates determined by near-infrared time-resolved spectroscopy. Pediat Res 58:568–573.PubMedCrossRefGoogle Scholar
Oda M, Nakano T, Suzuki A et al. (2000) Near infrared time-resolved spectroscopy system for tissue oxygenation monitor. SPIE 4160:204–210.CrossRefGoogle Scholar
Patterson MS, Chance B, Wilson BC (1989) Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties. Appl Opt 28:2331–2336.PubMedCrossRefGoogle Scholar
Tromberg BJ, Coquoz O, Fishkin JB et al. (1997) Noninvasive measurements of breast tissue optical properties using frequency-domain photon migration. Philos Trans R Soc Lond B 352:661–668.CrossRefGoogle Scholar
Okada Y, Shima T, Nishida M et al. (1999) Comparison of transcranial Doppler investigation of aneurysmal vasospasm with digital subtraction angiographic and clinical findings. Neurosurgery 43:443–449.CrossRefGoogle Scholar
Okada E, Delpy DT (2003) Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer. Appl Opt 42:2906–2914.PubMedCrossRefGoogle Scholar
Boas DA, Gaudette T, Strangman G et al. (2001) The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. NeuroImage 13:76–90.PubMedCrossRefGoogle Scholar
Liebert A, Wabnitz H, Steinbrink J et al. (2005) Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. NeuroImage 24:426–435.PubMedCrossRefGoogle Scholar
Karibe H, Tominaga T, Sato K et al. (2001) Decrease in intraoperative brain surface temperature in patients with subarachnoid haemorrhage. Acta Neurochir (Wien) 143:9–14.CrossRefGoogle Scholar