FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization

  • Jianting Wang
  • Michael H. Nantz
  • Samuel Achilefu
  • Kyung A. Kang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)


Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.


Tannic Acid Fluorescence Quenching Indocyanine Green Fluorescence Change Molecule Number 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Authors acknowledge U.S. Army (DoD) Breast Cancer Program (BC074387) for the financial support.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jianting Wang
    • 1
  • Michael H. Nantz
    • 2
  • Samuel Achilefu
    • 3
  • Kyung A. Kang
    • 1
  1. 1.Department of Chemical EngineeringUniversity of LouisvilleLouisvilleUSA
  2. 2.Department of ChemistryUniversity of LouisvilleLouisvilleUSA
  3. 3.Department of RadiologyWashington University School of MedicineSt. LouisUSA

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