FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization

  • Jianting Wang
  • Michael H. Nantz
  • Samuel Achilefu
  • Kyung A. Kang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)

Abstract

Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.

Keywords

Surfactant Platinum Dicyclohexylcarbodiimide 

Notes

Acknowledgments

Authors acknowledge U.S. Army (DoD) Breast Cancer Program (BC074387) for the financial support.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jianting Wang
    • 1
  • Michael H. Nantz
    • 2
  • Samuel Achilefu
    • 3
  • Kyung A. Kang
    • 1
  1. 1.Department of Chemical EngineeringUniversity of LouisvilleLouisvilleUSA
  2. 2.Department of ChemistryUniversity of LouisvilleLouisvilleUSA
  3. 3.Department of RadiologyWashington University School of MedicineSt. LouisUSA

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