Theoretical and Experimental Investigation of the Influence of Frontal Sinus on the Sensitivity of the NIRS Signal in the Adult Head
The sensitivity of the near-infrared spectroscopy signal to the brain activation depends on the thickness and structure of the superficial tissues. The influence of the frontal sinus, which is void region in the skull, on the sensitivity to the brain activation is investigated by the time-resolved experiments and the theoretical modelling of the light propagation in the head. In the time-resolved experiments, the mean-time of flight for the forehead scarcely depends upon the existence of the frontal sinus when probe spacing was shorter than 30 mm. The partial optical path length in the brain, which indicates the sensitivity of the near-infrared spectroscopy signal to the brain activation, in a simplified head model is predicted by Monte Carlo simulation. The influence of the frontal sinus on the sensitivity of the signal depends on the thickness of the skull and the depth of the frontal sinus.
KeywordsBrain Activation Probe Spacing Point Spread Function Subarachnoid Space Light Propagation
This work was partly supported by Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B) (19360035) and by a Grant-in-Aid for the Global Center of Excellence for High-Level Global Cooperation for Leading-Edge Platform on Access Spaces from the Ministry of Education, Culture, Sport, Science, and Technology in Japan.
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