Renal Vasoconstriction in Rats Causes a Decrease in Capillary Density and an Increase in Alkaline Phosphatase Expression in Cardiac Capillary Nets

  • Tomiyasu Koyama
  • Akira Taka
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)


In the rat, experimental renal vasoconstriction induced by the use of a Goldblatt clamp caused arterial hypertension, cardiomyocyte hypertrophy and an increased capillary to cardiomyocyte ratio, the latter indicating the formation of new cardiac capillaries. Total capillary density decreased, but capillary portions expressing alkaline phosphatase increased. This suggested a greater arterialization of capillaries which would increase the flow of arterial blood to the myocardial capillary nets. However, the observed increase in the area of the capillary domains means the extra arterialization was not sufficient to compensate for the lengthening of the oxygen diffusion pathway caused by the hypertrophy. Since the effects of renal vasoconstriction were not seen in rats treated with an inhibitor of angiotensin converting enzyme (ACE) it is suggested they are induced by angiotensin II via activation of the renin-angiotensin system (RAS).


Angiotensin Converting Enzyme Aortic Constriction Left Renal Artery Renal Vasoconstriction Systolic Arterial Blood Pressure 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Hokkaido UniversitySapporoJapan
  2. 2.Sapporo-Aoba School of Holistic MedicineSapporoJapan

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