Abstract
Force microscopy, originally named atomic force microscopy by the inventors (Binnig et al., 1986), is a new type of measuring instrument in the nanometer range, down to the size of single atoms, developed after the invention of the scanning tunneling microscope (Binnig et al., 1982). These microscopes represent not only new types of imaging instruments, hence the term “microscopes,” but, more importantly, a new technology called scanning probe techniques (SPT). With these methods, one can measure and manipulate in the nanometer range in any environment, opening up a new field of interdisciplinary experimental science. The common features of these microscopes are a measurable and strongly distance-dependent parameter, a probe small enough for the desired spatial resolution, and a mechanism to scan over a surface with the necessary stability.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Binnig, G., Rohrer, H., Gerber, C., and Weibel, E., 1982, Surface study by scanning tunneling microscopy, Phys. Rev. Lett 49: 57–60.
Binnig, G., Quate, C. F., and Gerber, C., 1986, Atomic force microscope, Phys. Rev. Lett 56: 930–933.
Bryant, A., Smith, D. P. E., Ohnesorge, E, Weisenhorn, A. J., Heyn, S. P., Drake, B., Prater, C. B., Gould, S. A., Hansma, P. A., and Gaub, H., and Quate, C. F., 1986, Appl. Phys. Lett 48: 832–834.
Egger, M., Ohnesorge, F., Weisenhorn, A. J., Heyn, S. P., Drake, B., Prater, C. B., Gould, S. A.
Hansma, P. A., and Gaub, H., 1990, Wet lipid—protein membranes imaged at submolecular resolution by atomic force microscopy, J. Struct. Biol 103: 89–94.
Fuchs, H., Schrepp, W., and Rohrer, H., 1987, STM investigations of Langmuir—Blodgett films, Surf. Sci 181: 391–393.
Guckenberger, R., Weigrabe, W., Hillebrand, A., Hartmann, T., Wang, Z., and Baumeister, W., 1989, Scanning tunneling microscopy of a hydrated bacterial surface protein, Ultramicroscopy 31: 327–331.
Häberle, W., Hörber, J. K. H., and Binnig, G., 1989, Force microscopy on living cells, J. Vac. Sci.Technol B9: 1210–1212.
Hansma, P. K., Drake, B., Marti, O., Gould, S. A. C., and Prater, C. B., 1989, The scanning ion conductance microscope, Science 243: 641–643.
Hong, K., and Driscoll, M., 1994, A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans, Nature 367: 470–474.
Hörber J. K. H., Lang, C. A., Hänsch, T. W., Heckl, W. M., and Möhwald, H., 1988, Scanning tunneling microscopy of lipid films and embedded biomolecules, Chem. Phys. Leu 145: 151–154.
Hörber, J. K. H., Schuler, F. M., Witzemann, W., Schröder, K. H., and Müller, H., 1991, Imaging of cell membrane proteins with a scanning tunneling microscope, J. Vac. Sci. Technol B9: 1214–1218.
Hörber, J. K. H., Häberle, W., Ohnesorge, F., Binnig, G., Liebich, H. G., Czerny, C. P., Mahnel, H., and Mayr, A., 1992, Investigation of living cells in the nanometer regime with the scanning force microscope, Scan. Microsc 6: 919–929.
Huang, M., and Chalfie, M., 1994, Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans, Nature 367: 467–470.
Hudspeth, A. J., and Gillespie, P. G., 1994, Pulling springs to tune transduction: Adaption by hair cells, Neuron 12: 1–9.
Israelachvili, J. N., 1992, Intermolecular and Surface Forces, 2nd. ed., Academic Press, San Diego. Jericho, M. H., Blackford, B. D., Dahn, D. C., Frame, C., and Maclean, D., 1990, Scanning tunneling microscopy imaging of uncoated biological material, J. Vac. Sci. Technol 88: 661–666.
Martin, Y., and Wickramasinghe, H. K., 1988, High resolution capacitance measurement and potentiometry by force microscopy, Appl. Phys. Lett 52: 1103.
Matey, J. R., and Blanc, J., 1985, Scanning capacitance microscopy J. Appl. Phys. 57:1437–1439. Methfessel, C., Witzemann, V., Takahashi, T., Mishima, M., Numa, S., and Sakmann, B., 1986, Patch clamp measurements on Xenopus laevis oocytes: Currents through endogenous channels and implanted acetylcholine receptor and sodium channels, Pflügers Arch. 407: 577–588.
Meyer, E., Howald, L., Overney, R. M., Heinzelmann, H., Frommer, J., Guntherodt, H.-J., Wagner, T., Schier, H., and Roth, S., 1989, Molecular-resolution images of Langmuir—Blodgett films using atomic force microscopy, Nature 349: 398–399.
Meyer, G., and Am, N. M., 1988, Novel optical approach to atomic force microscopy, Appl. Phys. Lett 53: 1045–1047.
Pohl, D. W., Fischer, U. C., and Dtirig, U. T., 1988, Scanning near-field optical microscopy (SNOM), J. Microsc 152: 853–861.
Sâenz, J. J., Garcia, N., Grutter, E, Meyer, E., Heinzelmann, H., Wiesendanger, R., Rosenthaler, L., Hidber, H. R., and Guntherodt, H.-J., 1987, Observation of magnetic forces by the atomic force microscope, J. Appl. Phys 62: 4293–4295.
Smith, D. P. E., Bryant, A., Quade, C. F., Rabe, J. P., Berger, Ch., and Swalen, J. D., 1987, Images of a lipid bilayer at molecular resolution by scanning tunneling microscopy, Proc. Natl. Acad. Sci. U.S.A 84: 969–972.
Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R., and Kung, C., 1994, A large-conductance mechanosensitive channel in E. coli encoded by mscL alone, Nature 368: 265–268.
Williams, C. C., and Wickramasinghe, H. K., 1988, Thermal and photo thermal imaging on a sub 100 nm scale, Proc. SPIE 897: 129.
Worcester, D. L., Miller, R. G., and Bryant, P. J., 1988, Atomic force microscopy of purple membranes, J. Microsc 152: 817–821.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hörber, J.K.H., Mosbacher, J., Häberle, W. (1995). Force Microscopy on Membrane Patches. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1229-9_17
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1229-9_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-1230-5
Online ISBN: 978-1-4419-1229-9
eBook Packages: Springer Book Archive