Thrombosis and Bleeding in Cancer Patients



Cancer patients are known to exhibit a hypercoagulable state with a high risk for thrombosis and pulmonary embolism. Recent data suggest that thromboprophylaxis in cancer patients is likely to be underused. This is important as there is some evidence that the use of low molecular weight heparin (LMWH) improves the response to chemotherapy and is also likely to be able to improve survival. In the palliative care setting, patients seem willing to accept the use of subcutaneous LMWH injections as compared to compression stockings because of the greater efficacy.

Research has also shown that the provident, structured use of blood products in patients undergoing chemotherapy reduces the need for them and therefore potential side effects to the patients. This also leads to reduced resource consumption and thus reduced economic strain on the healthcare system. Bleeding complications in cancer patients undergoing surgery are not infrequent and have recently been linked to reduced crosslinking capacity. Novel strategies for perioperative risk stratification in cancer patients have been developed. More clinical research is needed to improve our understanding of thrombosis and bleeding in cancer patients.


Acute Myelogenous Leukemia Polycythemia Vera Coagulation Activation Compression Stocking Portal Vein Tumor Thrombus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Society for Imaging Informatics in Medicine 2010

Authors and Affiliations

  1. 1.Institute for Clinical Chemistry and HematologyKantonsspital St. GallenSt. GallenSwitzerland
  2. 2.University of BernBernSwitzerland

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