Exercise for Prevention and Treatment of Prostate Cancer: Cellular Mechanisms
Numerous epidemiological studies suggest that PA might reduce the risk for PCa but there are many inconsistencies in the data. Little is known about the value of exercise after diagnosis of PCa. Two studies report that resistance training during ADT increases muscular strength and reduces fatigue with no changes in body composition or in serum levels of testosterone or PSA. One study investigated the effects of aerobic exercise training on PCa patients during external beam RT and found an improvement in physical function with reduced fatigue. These were short-term studies with no PCa clinical outcomes. In a 1-year study, regular exercise combined with a low-fat, vegan diet and stress reduction reduced the need for aggressive treatment of the PCa. In obese men with no documented PCa, regular exercise, especially when combined with a low-fat diet, has been shown to reduce serum insulin and IGF-I, while increasing IGFBP-1 and SHBG. These serum changes result in reduced growth and increased apoptosis of androgen-dependent PCa cell lines in cultures. The effects on tumor cells appear to be associated with activation of the p53 gene and suggest that lifestyle modification may be important for both the prevention and treatment of PCa.
KeywordsResistance Training Exercise Intervention LNCaP Cell Exercise Group Cell Death Detection ELISA
This work was supported by NCI Specialized Program of Research Excellence Grant P50 CA-921310, NCI Grant R01 CA-100938, The Veterans Administration, and a donation from the L.B. Research and Education Foundation.
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