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APC in Cell Migration

  • Sandrine Etienne-Manneville
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 656)

Abstract

Adenomatous Polyposis Coli (APC) is a tumor suppressor protein involved in the initiation and progression of colon cancer. The most widely accepted function of APC is to participate to the Wnt signaling pathway, by downregulating β-catenin and thereby controlling gene transcription and cell proliferation. However, APC is clearly a multifunctional protein whose loss contributes to tumor formation in multiple ways. Regulation of APC localization during cell migration and the ability of APC to bind multiple polarity proteins and microtubule-associated molecules support the idea that APC plays a key role in directed cell migration and that this function may contribute to its tumour suppressor activity.

Keywords

Adenomatous Polyposis Coli Epithelial Cell Migration Adenomatous Polyposis Coli Protein Colorectal Tumour Cell Suppressor Adenomarous Polyposis Coli 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Cell Polarity and Migration GroupInstitut Pasteur CNRS URA 2582Paris cedex15France

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