Conotoxin Venom Peptide Therapeutics

  • Richard J. Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 655)


Venom peptides offer enormous opportunity for the discovery of peptide drug leads. This review focusses on the potential of cone snails that have developed arrays of small peptides as part of highly evolved venoms used for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology. A number of these conopeptides reduce pain in animals models and several are now in preclinical and clinical development for the treatment of severe pain often associated with diseases such as cancer.


Cone Snail Calcium Channel Inhibitor Neuronal Calcium Channel Sodium Channel Inhibitor Sodium Channel Subtype 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Richard J. Lewis
    • 1
  1. 1.Xenome Ltd, Indooroopilly 4068 and Institute for Molecular BiosciencesThe University of QueenslandBrisbaneAustralia

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