Abstract
The potential applications of nanotechnology in life sciences, particularly nanobiotechnology, include those for drug discovery. This chapter shows how several of the nanotechnologies including nanoparticles and various nanodevices such as nanobiosensors and nanobiochips are being used to improve drug discovery. Nanoscale assays using nanoliter volumes contribute to cost saving. Some nanosubstances such as fullerenes are drug candidates. There are some safety concerns about the in vivo use of nanoparticles that are being investigated. However, future prospects for applications in healthcare of drugs discovered through nanotechnology and their role in the development of personalized medicine appear to be excellent.
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References
Jain KK. Nanobiotechnology: applications, markets and companies. Jain PharmaBiotech Publications, Basel: Switzerland, 2007:1–695.
Jain KK. Nanobiotechnology in Molecular Diagnostics. Norwich, UK: Horizon Scientific Press, 2006:1–185.
Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov Today 2005; 10:1435–1442.
Ozkan M. Quantum dots and other nanoparticles: what can they offer to drug discovery? Drug Discov Today 2004; 9:1065–71.
Farrer RA, Butterfield FL, Chen VW et al. Highly efficient multiphoton-absorption-induced luminescence from gold nanoparticles. Nano Lett 2005; 5:1139–42.
Balthasar S, Michaelis K, Dinauer N et al. Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes. Biomaterials 2005; 26:2723–32.
Jain KK. Nanoparticles as targeting ligands. Trends Biotechnol 2006 Apr; 24:143–5.
Won J, Kim M, Yi YW et al. A magnetic nanoprobe technology for detecting molecular interactions in live cells. Science 2005; 309:121–5.
Hsu HY, Huang YY. RCA combined nanoparticle-based optical detection technique for protein microarray: a novel approach. Biosens Bioelectron 2004; 20, 123–6.
Ziegler C. Cantilever-based biosensors. Anal Bioanal Chem 2004; 379:946–59.
Kukowska-Latallo JF, Candido KA, Cao Z et al. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res 2005; 65:5317–24.
Ali SS, Hardt JI, Quick KL et al. A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. Free Radic Biol Med 2004; 37:1191–202.
Revets H, De Baetselier P, Muyldermans S. Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther 2005; 5:111–24.
Jain KK. Personalized Medicine: scientific and commercial aspects. Basel: Jain PharmaBiotech, 2007:1–600.
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© 2009 Landes Bioscience and Springer Science+Business Media
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Jain, K.K. (2009). The Role of Nanobiotechnology in Drug Discovery. In: Guzmán, C.A., Feuerstein, G.Z. (eds) Pharmaceutical Biotechnology. Advances in Experimental Medicine and Biology, vol 655. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1132-2_4
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DOI: https://doi.org/10.1007/978-1-4419-1132-2_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1131-5
Online ISBN: 978-1-4419-1132-2
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