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RhoBTB Proteins in Cancer

Chapter

Abstract

The most peculiar members of the Rho GTPase family are the RhoBTB proteins - large, multimodular proteins that contain two copies of the BTB protein-protein interaction module. While we know very little of the signalling pathways controlled by RhoBTBs, they are some of the oldest members of the family, predating RhoA and Cdc42. While other Rho GTPase may have critical enabling roles in cancer, the RhoBTBs show the clearest evidence for genetic alteration - with loss, mutation, and silencing of the RhoBTB2 isoform being a seemingly common event in a wide range of carcinomas. While activation of other Rho GTPase pathways can promote invasion and metastasis, the RhoBTBs appear to have a protective role and may function as tumour suppressors.

Keywords

CXCL14 Expression Candidate Tumour Suppressor Promyelocytic Leukemia Zinc Finger Primary Human Bronchial Epithelial Cell Somatic Missense Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of BiochemistrySchool of Medical Sciences, University of Bristol, University WalkBristolUK

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