Signaling through Galpha12/13 and RGS-RhoGEFs
The transforming heterotrimeric G proteins Gα12 and Gα13 have been implicated in the regulation of various cellular processes, such as gene transcription and rearrangement of the actin-based cytoskeleton. Many of these functions are dependent on the activation of the monomeric GTPase RhoA. The RGS-RhoGEFs, a distinct family of guanine nucleotide exchange factors, which contain RGS-like domains in their N-termini, serve as direct links between Gα12/13 and RhoA. The focus of this chapter is on the molecular mechanisms that underlie and regulate signaling from Gα12/13 to RhoA via the RGS-RhoGEFs. The physiological significance of this signaling pathway is also discussed.
KeywordsAcute Myeloid Leukemia Guanine Nucleotide Exchange Factor Neurite Retraction Guanine Nucleotide Exchange Activity Nucleotide Exchange Rate
We would like to apologize to our colleagues whose contributions to this field were inadvertently omitted or could not be properly acknowledged due to space limitations.
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