RhoGDIs in Cancer

  • Anthony N. Anselmo
  • Gary M. Bokoch
  • Céline DerMardirossian


The dynamics of Rho GTPase action are regulated by both an activity cycle and a cytosol-to-membrane cycle (Fig. 3.1). Rho GTPases are activated by the exchange of bound GDP for ambient GTP, which is stimulated by guanine nucleotide exchange factors (GEFs) and are inactivated by hydrolysis of bound GTP to GDP catalyzed by GTPase-activating proteins (GAPs). This activity cycle is regulated by guanine nucleotide dissociation inhibitors (GDIs), which act to sterically shield the Rho GTPases from the action of GEFs and GAPs. Thus for Rho GTPases to become active, it is thought that they must first be released from GDIs in order for membrane-associated GEFs to catalyze activation. Superimposed on this activity cycle is a cytosol/membrane cycle that is directly controlled by Rho GDIs (see below).


Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Phosphatidic Acid Raji Cell T24T Cell 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Anthony N. Anselmo
    • 1
  • Gary M. Bokoch
    • 1
  • Céline DerMardirossian
    • 1
  1. 1.Departments of Immunology and Cell BiologyThe Scripps Research InstituteLa JollaUSA

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