Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview



As discussed in Parts I and II of this book the Rho GTPases are highly regulated in their ability to become activated. The concept that there are many more guanine exchange factorss and GTPase-activating proteinss than Rho proteins, and given the function of the Rho guanine dissociation inhibitors (RhoGDIs), they would lead to the conclusion that all regulation occurs on the level of the Rho regulatory proteins. However, evidence that implicates phosphorylation events as being additional mechanisms for controlling Rho activity and potential interactions with downstream effectors is emerging. This chapter provides a brief overview of Rho phosphorylation events via the activity of four well-studied protein kinases: protein kinase A, protein kinase B (aka Akt), protein kinase C, and protein kinase G.


GTPase Activity Active RhoA Inflammatory Breast Cancer Cell RhoC GTPase SUM149 Inflammatory Breast Cancer 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Biological Sciences, Laboratory of Cytoskeletal PhysiologyUniversity of Delaware, Center for Translational Cancer ResearchNewarkUSA

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