The Future of Vaccine Discovery and Development
The science and practice of vaccination were initially based on multiple historical observations that related the acquisition of protection against a specific microbe to a previous exposure to the same agent (Hilleman 2003). Although, in modern history, the practice was confined to inducing protection against infectious diseases, its historical roots extended to exposures to toxins, and its current conceptual framework encompasses many more pathological conditions, such as cancer (Finn 2008). Fundamentally, vaccination aims at inducing host immune responses to mount preventive or therapeutic defenses against diseases of varying etiologies, including those of infectious, and potentially autoimmune or neoplastic origin. This chapter defines our current understanding of the challenges facing the discovery and development of new vaccines for a variety of disease conditions; the aim is to identify the critical steps in exploring future imperatives and directions.
KeywordsSmallpox Vaccine Recombinant HBsAg Vaccine Discovery Immunogen Identification Protective Immunogen
- Hilleman M (2003) Overview of vaccinology in historic and future perspective: The whence and whithers of a dynamic sequence with complex dimensions. In: Hildegend C (ed) DNA vaccines. Academic/Plennum Publishers, New YorkGoogle Scholar