Japanese Encephalitis



Summer-fall encephalitis outbreaks, consistent with Japanese encephalitis (JE), were recorded in Japan as early as 1871; the largest, in 1924, involved more than 6,000 cases, 60% of them fatal (Hiroyama 1962). A filterable agent from human brain tissue was isolated in rabbits that year and in 1934, Hayashi transmitted the disease experimentally to monkeys by the intracerebral inoculation of human brain suspension (Hayashi 1934; Inada 1937). The virus was subsequently adapted to mice, and soon after, a serological diagnostic test was developed based on the presence of specific neutralizing antibody in recovered patients (Hayashi 1934; Kawamura et al. 1936; Taniguchi et al. 1936). Inoculation of mouse brain with JE and related St. Louis encephalitis (SLE) flaviviruses provided antigens that enabled workers to confirm encephalitis cases serologically, including a cluster of cases that occurred in 1934 and 1935 in Beijing (Kuttner and Tsun 1936).


Japanese Encephalitis Virus Japanese Encephalitis Japanese Encephalitis Japanese Encephalitis Vaccine Japanese Encephalitis Case 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Supportive Research and Development Program, Pediatric Dengue Vaccine InitiativeInternational Vaccine InstituteSeoulKorea

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