Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance



Survival of an organism is reliant on preservation of genomic integrity. The RecQ helicase family of proteins plays crucial roles in maintaining genomic stability. DNA repair processes are very important for restoring the damaged DNA, and increasing lines of evidence suggest that RecQ helicases are involved in these processes. Telomeres are situated at the end of linear chromosomes, where they play key roles in the preservation of genome stability. Telomerase and telomere protein complexes play key roles in telomere length regulation. The latter, referred as the shelterin complex, also acts on telomere-specific structures and telomere capping. Other telomere-associated proteins are involved in the proper processing of telomere length, structure and capping. RecQ helicases, especially WRN, are also believed to be involved in the maintenance of telomeres. They are implicated in replication, recombination and proper repair of telomeric DNA.


Base Excision Repair Replication Fork Sister Chromatid Exchange Werner Syndrome Holliday Junction 





Alternative lengthening of telomeres


Base excision repair


Bloom syndrome


Double-strand break


Double-strand break repair


Double-stranded DNA


Fluorescence in situ hybridization




Holiday junction


Homologous recombination


Interstrand crosslink


Long patch base excision repair


Mismatch repair


Nucleotide excision repair


Nonhomologous end-joining


Reactive oxygen species


Rothmund–Thomson syndrome


RecQ Conserved


Single-strand break repair


Sister chromatid exchange


Short-patch base excision repair


Single-stranded DNA


Telomere dysfunction-induced foci


Werner syndrome



This work was supported in part by funds from the National Institute on Aging, National Institutes of Health Intramural Research Program.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Laboratory of Molecular GerontologyBaltimoreUSA

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