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Malignant Lymphoma

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Atlas of Pediatric Brain Tumors

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Abstract

Represent primary CNS extranodal lymphomas and should be distinguished from clinical scenarios in which the CNS is involved secondarily by a primary nodal or extranodal systemic lymphoma. Primary central nervous system lymphoma (PCNSL) represents 5% of all primary brain tumors in adults. Occurs primarily in older individuals or in immunocompromised states. Significant rise in incidence was noted in the 1980s and 1990s which was partly due to AIDS. An increased incidence was also noted in the immunocompetent and particularly young adults but current data suggest that incidence has stabilized. Secondary leptomeningeal involvement of the CNS is the more common form of involvement of the CNS by hematologic malignancies and is the rationale for CNS prophylaxis in childhood leukemias.

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Author information

Authors and Affiliations

  1. Section of Neuropathology and Molecular Neuropathology Laboratory, Department of Pathology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

    Adekunle M. Adesina M.D., Ph.D. (Professor of Pathology, Medical Director)

Authors
  1. Adekunle M. Adesina M.D., Ph.D.
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Editors and Affiliations

  1. Dept. Pathology, Baylor College of Medicine, Baylor Plaza 1, Houston, 77030, U.S.A.

    Adekunle M. Adesina

  2. School of Medicine, University of California, Parnassus Ave. 505, San Francisco, 94143, U.S.A.

    Tarik Tihan

  3. VCU Medical Center, Virginia Commonwealth University, E. Marshall Street 1200, Richmond, 23298, U.S.A.

    Christine E. Fuller

  4. Children's Hospital Boston, Harvard Medical School, Longwood Ave. 300, Boston, 02115, U.S.A.

    Tina Young Poussaint

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Adesina, A.M. (2010). Malignant Lymphoma. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_35

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  • DOI: https://doi.org/10.1007/978-1-4419-1062-2_35

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1061-5

  • Online ISBN: 978-1-4419-1062-2

  • eBook Packages: MedicineMedicine (R0)

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