Ganglioglioma and Gangliocytoma
These are neuroepithelial tumors composed of mature neurons (gangliocytoma) or a mixed population of ganglion cells and glial cells (ganglioglioma). Well differentiated gangliocytomas are classified as WHO grade I while gangliogliomas may be classified as WHO grade I or II. Anaplastic ganglioglioma with a malignant glial component is classified as WHO grade III. Gangliogliomas and gangliocytomas may occur in all age groups but they are frequently seen in the young with a peak between the age of 10 and 30 years and representing about 0.4% of all tumors in the central nervous system.
KeywordsGanglioglioma Glioneuronal Pilocytic Gangliocytoma DNET-ganglioglioma overlap
- Karremann M, Pietsch T, Janssen G, Kramm CM, Wolff JE (2009) Anaplastic ganglioglioma in children. J Neurooncol 92(2):152–163Google Scholar
- Brat DJ, Parisi JE, Kleinschmidt-DeMasters BK, Yachnis AT, Montine TJ, Boyer PJ, Powell SZ, Prayson RA, McLendon RE (2008) Surgical neuropathology update: A review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edn. Arch Pathol Lab Med 132(6):993–1007, ReviewGoogle Scholar
- Mittelbronn M, Schittenhelm J, Lemke D, Ritz R, Nägele T, Weller M, Meyermann R, Beschorner R (2007) Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components. Neuropathology 27(5):463–467PubMedCrossRefGoogle Scholar