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Dysembryoplastic Neuroepithelial Tumor

  • Adekunle M. Adesina
  • Ronald A. Rauch
Chapter

Abstract

Superficial cortical, benign glioneuronal neoplasms, WHO grade I, often associated with the long-standing history of refractory partial complex seizures. Characteristically uninodular or multinodular lesions accompanied by cortical dysplasia. Represents 12 and 13.5% of histologic findings in adults and children, respectively, receiving epileptic surgery.

Keywords

Microcystic pattern glioneuronal tumor developmental tumor cortical dysplasia seizure related neoplasia 

Suggested Reading

  1. Sung CO, Suh YL (2009) Different pattern of expression of nestin in the non-specific form of dysembryoplastic neuroepithelial tumors compared to the simple and complex forms. J Neurooncol 92(1):7–13Google Scholar
  2. Maher CO, White JB, Scheithauer BW, Raffel C (2008) Recurrence of dysembryoplastic neuroepithelial tumor following resection. Pediatr Neurosurg 44(4):333–336PubMedCrossRefGoogle Scholar
  3. O’Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS (2007) The Children’s Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. Br J Neurosurg 21(6):539–549PubMedCrossRefGoogle Scholar
  4. Ishizawa K, Terao S, Kobayashi K, Yoshida K, Hirose T (2007) A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor and pleomorphic xanthoastrocytoma–a case report and review of the literature. Clin Neuropathol 26(4):169–175 ReviewPubMedGoogle Scholar
  5. Sherburn EW, Bahn MM, Gokden M, Silbergeld DL, Rich KM (1998) Dysembryoplastic neuroepithelial tumor and oligodendroglioma: The diagnostic value of magnetic resonance spectroscopy. Case report and review of the literature. Neurosurg Focus 4(4):e6PubMedCrossRefGoogle Scholar
  6. Deb P, Sharma MC, Tripathi M, Sarat Chandra P, Gupta A, Sarkar C (2006) Expression of CD34 as a novel marker for glioneuronal lesions associated with chronic intractable epilepsy. Neuropathol Appl Neurobiol 32(5):461–468PubMedCrossRefGoogle Scholar
  7. Takahashi A, Hong SC, Seo DW, Hong SB, Lee M, Suh YL (2005) Frequent association of cortical dysplasia in dysembryoplastic neuroepithelial tumor treated by epilepsy surgery. Surg Neurol 64(5):419–427PubMedCrossRefGoogle Scholar
  8. Sakuta R, Otsubo H, Nolan MA, Weiss SK, Hawkins C, Rutka JT, Chuang NA, Chuang SH, Snead OC III (2005) Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor. J Child Neurol 20(4):377–384PubMedCrossRefGoogle Scholar
  9. Park JY, Suh YL, Han J (2003) Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. Acta Cytol 47(4):624–629PubMedCrossRefGoogle Scholar
  10. Prayson RA, Castilla EA, Hartke M, Pettay J, Tubbs RR, Barnett GH (2002) Chromosome 1p allelic loss by fluorescence in situ hybridization is not observed in dysembryoplastic neuroepithelial tumors. Am J Clin Pathol 118(4):512–517PubMedCrossRefGoogle Scholar
  11. Stanescu Cosson R, Varlet P, Beuvon F, Daumas Duport C, Devaux B, Chassoux F, Frédy D, Meder JF (2001) Dysembryoplastic neuroepithelial tumors: CT, MR findings and imaging follow-up: A study of 53 cases. J Neuroradiol 28(4):230–240PubMedGoogle Scholar
  12. Daumas-Duport C, Varlet P, Bacha S, Beuvon F, Cervera-Pierot P, Chodkiewicz JP (1999) Dysembryoplastic neuroepithelial tumors: Nonspecific histological forms – a study of 40 cases. J Neurooncol 41(3):267–280PubMedCrossRefGoogle Scholar
  13. Honavar M, Janota I, Polkey CE (1999) Histological heterogeneity of dysembryoplastic neuroepithelial tumour: Identification and differential diagnosis in a series of 74 cases. Histopathology 34(4):342–356PubMedCrossRefGoogle Scholar
  14. Prayson RA (1999) Composite ganglioglioma and dysembryoplastic neuroepithelial tumor. Arch Pathol Lab Med 123(3):247–250PubMedGoogle Scholar
  15. Hirose T, Scheithauer BW (1998) Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma. Acta Neuropathol 95(6):649–654 ReviewPubMedCrossRefGoogle Scholar
  16. Ostertun B, Wolf HK, Campos MG, Matus C, Solymosi L, Elger CE, Schramm J, Schild HH (1996) Dysembryoplastic neuroepithelial tumors: MR and CT evaluation. AJNR Am J Neuroradiol 17(3):419–430PubMedGoogle Scholar
  17. Taratuto AL, Pomata H, Sevlever G, Gallo G, Monges J (1995) Dysembryoplastic neuroepithelial tumor: Morphological, immunocytochemical, and deoxyribonucleic acid analyses in a pediatric series. Neurosurgery 36(3):474–481PubMedCrossRefGoogle Scholar
  18. Hirose T, Scheithauer BW, Lopes MB, VandenBerg SR (1994) Dysembryoplastic neuroeptihelial tumor (DNT): An immunohistochemical and ultrastructural study. J Neuropathol Exp Neurol 53(2):184–195PubMedCrossRefGoogle Scholar
  19. Daumas-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathol 3(3):283–295 ReviewPubMedCrossRefGoogle Scholar
  20. Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER Jr, Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: A surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. Neurosurgery 23(5):545–556PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Adekunle M. Adesina
    • 1
  • Ronald A. Rauch
    • 2
  1. 1.Section of Neuropathology and Molecular Neuropathology Laboratory, Department of PathologyTexas Children’s Hospital, Baylor College of MedicineHoustonUSA
  2. 2.Department of Radiology, Texas Children’s Hospital, Baylor College of MedicineTexas Children’s Hospital, Baylor College of MedicineHoustonUSA

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