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Regulation of Bone Formation and Immune Cell Development by Schnurri Proteins

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 658)

Abstract

Although identified over a decade ago, the function and physiological significance of the mammalian Schnurri protein family remained largely unknown. However, the recent generation and characterization of mice bearing null mutations in the individual Schnurri genes has led to the discovery of unexpected yet central roles for these large zinc-finger proteins in several biological processes. Here, we review findings of these studies and discuss the importance of the Schnurri protein family in regulating both the immune and skeletal systems.

Keywords

Schnurri Skeletal system Immune system Osteoblasts T lymphocytes 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Infectious Disease and ImmunologyHarvard School of Public HealthBostonUSA
  2. 2.Department of Infectious Disease and Immunology, Harvard School of Public Health and Department of MedicineHarvard Medical School, Brigham and Women´s HospitalBostonUSA

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