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Synaptic Plasticity at Hippocampal Synapses

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Book cover Hippocampal Microcircuits

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 5))

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Abstract

This chapter will discuss what is currently known about synaptic plasticity at glutamatergic synapses in the hippocampus. Hippocampal synaptic plasticity is potentially a vast topic with many thousands of research papers published in the field. However, this chapter will not discuss the detailed molecular mechanisms underlying synaptic plasticity and instead will concentrate on the precise activity patterns required to induce synaptic plasticity. This includes the contribution of presynaptic and postsynaptic spiking and the importance of subthreshold postsynaptic depolarisation. Also, this chapter will attempt to relate various induction protocols to known in vivo patterns of neuronal activity.

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Authors and Affiliations

  1. MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol, BS8 1TD, UK

    Jack Mellor

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  1. Jack Mellor
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Correspondence to Jack Mellor .

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  1. Department of Computing Science and Mathematics, University of Stirling, Stirling, FK9 4LA, UK

    Vassilis Cutsuridis  & Bruce Graham  & 

  2. Neuroscience & Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK

    Stuart Cobb  & Imre Vida  & 

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Mellor, J. (2010). Synaptic Plasticity at Hippocampal Synapses. In: Cutsuridis, V., Graham, B., Cobb, S., Vida, I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0996-1_6

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