Fast and Slow GABAergic Transmission in Hippocampal Circuits

  • Marlene Bartos
  • Jonas-Frederic Sauer
  • Imre Vida
  • Ákos Kulik
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 5)


Cortical neuronal networks consist of excitatory glutamatergic principal cells and a heterogeneous group of GABAergic inhibitory interneurons. Interneurons are embedded in feedforward and feedback microcircuits and control key aspects of cortical network function including the timing of the activation of principal cells and the generation of network oscillations (Freund and Buzsáki, 1996; McBain and Fisahn, 2001; Klausberger and Somogyi, 2008). Although interneurons comprise only 10% of the neuronal population, they are highly diverse and can be subdivided into several types on the basis of various criteria, such as intrinsic physiological properties, neurochemical marker content, morphological features, including the laminar distribution of the axon, and finally the postsynaptic target profile of their output (Freund and Buzsáki, 1996; Avoli et al., 2006). On the basis of synaptic targets, interneurons have been classified into two major groups, perisomatic- and dendrite-targeting cells.


Pyramidal Cell Principal Cell Decay Time Constant Kir3 Channel Paired Recording 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Marlene Bartos
    • 1
  • Jonas-Frederic Sauer
    • 2
  • Imre Vida
    • 3
  • Ákos Kulik
    • 4
  1. 1.School of Medicine, Institute of Medical Sciences (IMS)University of AberdeenAberdeenUK
  2. 2.Institute of Medical SciencesUniversity of AberdeenAberdeenUK
  3. 3.Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life SciencesUniversity of GlasgowGlasgowUK
  4. 4.Department of Anatomy and Cell BiologyUniversity of FreiburgFreiburgGermany

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