Biophysics-Based Models of LTP/LTD

  • Gastone C. Castellani
  • Isabella Zironi
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 5)


Synaptic plasticity is the process by which neurons change the efficacy (or the strength) of their connections (synapses). In the connectionist paradigm, synaptic plasticity is a central concept because it is widely accepted that memory and learning are biologically encoded by variations of neuronal connections strength. In a more general sense, activity-dependent synaptic plasticity is assumed to be necessary and sufficient to encode and store memory in specific brain areas. Another feature of synaptic plasticity is the bidirectionality, which is the capability to increase or decrease the synaptic weights, thus encompassing the classical Hebbian paradigm.


Synaptic Plasticity AMPA Receptor GluR1 Subunit NR2A Subunit Inhibitory Avoidance Learning 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Dipartimento di Fisica Università di Bologna and Institute for Brain and Neural SystemsBrown UniversityBolognaItaly
  2. 2.Dipartimento di FisicaUniversità di BolognaBolognaItaly

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