Biophysics-Based Models of LTP/LTD
Synaptic plasticity is the process by which neurons change the efficacy (or the strength) of their connections (synapses). In the connectionist paradigm, synaptic plasticity is a central concept because it is widely accepted that memory and learning are biologically encoded by variations of neuronal connections strength. In a more general sense, activity-dependent synaptic plasticity is assumed to be necessary and sufficient to encode and store memory in specific brain areas. Another feature of synaptic plasticity is the bidirectionality, which is the capability to increase or decrease the synaptic weights, thus encompassing the classical Hebbian paradigm.
KeywordsSynaptic Plasticity AMPA Receptor GluR1 Subunit NR2A Subunit Inhibitory Avoidance Learning
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