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Closing the Gap Between Neurobiology and Human Presbycusis: Behavioral and Evoked Potential Studies of Age-Related Hearing Loss in Animal Models and in Humans

  • James R. Ison
  • Kelly L. Tremblay
  • Paul D. Allen
Chapter
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 34)

Abstract

Any reader who has grown up with a pet dog cannot have failed to notice that the effects of advancing age in dogs are not very different from those apparent in aging grandparents, except that in calendar time they appear more rapidly. Although domesticated animals may present a special case compared with wild animals that hardly survive to the age of sexual maturity, a few wild animals do survive and they also exhibit these common effects of human aging. Very close to human sympathies are the observations of elderly chimpanzees by naturalists who, having followed their stable groups for many years, write that the rare creature that has successfully survived the challenges of the wild exhibits the same thinning hair, slow movements, and sagging and wrinkled facial skin as the elderly human (Hill et al. 2001). And given the laboratory studies of hearing in old monkeys (Bennett et al. 1983) and examinations of cochlear pathology in postmortem studies of aged pet dogs (Shimada et al. 1998), this wrinkled and slowly moving chimpanzee and the graying and arthritic dear old pet must both suffer from poor hearing as do elderly humans.

Keywords

Hearing Loss Hair Cell Inferior Colliculus Absolute Threshold Endocochlear Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported in part by National Institutes of Health Grants DC 007705 from the National Institute on Deafness and Communication Disorders to KLT and AG 09524 from the Institute on Aging and DC 05409 from the Institute on Deafness and Communication Disorders to JRI and PDA.

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • James R. Ison
    • 1
  • Kelly L. Tremblay
    • 2
  • Paul D. Allen
    • 3
  1. 1.Department of Brain & Cognitive SciencesUniversity of RochesterRochesterUSA
  2. 2.Department of Speech & Hearing SciencesUniversity of WashingtonSeattleUSA
  3. 3.Department of Neurobiology & AnatomyUniversity of RochesterRochesterUSA

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