Cell Biology and Physiology of the Aging Central Auditory Pathway

  • Barbara Canlon
  • Robert Benjamin Illing
  • Joseph Walton
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 34)


The most common manifestation of age-induced hearing loss, presbycusis, is the loss of sensitivity for high-frequency sounds, resulting in difficulties in speech perception, hearing in noisy backgrounds, and distorted loudness perception. These abnormalities typically involve progressive damage to the inner ear and spiral ganglion neurons, leading to a diminished input into the central auditory nervous system. The central components of the auditory system can also undergo direct morphological and physiological changes induced by the biological effects of aging. A combination of direct and secondary changes is most likely to contribute to the manifestations of the aging auditory system. This chapter describes the cell biological and physiological changes that occur during aging in experimental subjects.


Inferior Colliculus Cochlear Nucleus Spiral Ganglion Neuron Dorsal Cochlear Nucleus Ventral Cochlear Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Barbara Canlon
    • 1
  • Robert Benjamin Illing
    • 2
  • Joseph Walton
    • 3
  1. 1.Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden
  2. 2.Neurobiological Research LaboratoryUniversitäts-HNO-KlinikFreiburgGermany
  3. 3.University of Rochester Medical CenterRochesterUSA

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