Vaccination Against Varicella: What's the Point?

  • Anne A. Gershon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 659)


Live attenuated varicella vaccine was developed in Japan in the early 1970 s as a means to prevent varicella primary infection with varicella-zoster virus (VZV) in healthy and immunocompromised individuals (Takahashi et al., 1974). Takahashi had attenuated the virus by passage in various cell cultures using different propagation temperatures and produced a candidate vaccine virus that proved to be both safe and immunogenic. Initially, there was great controversy as to whether it was likely to be safe to develop a vaccine that had the potential to become latent after immunization and that might even be oncogenic (Brunell, 1977, 1978). It was also questioned as to whether varicella was a serious enough disease to be worth preventing.


Cell Mediate Immunity Latent Infection Leukemic Child Measle Vaccine Varicella Vaccine 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PediatricsColumbia University College of Physicians and SurgeonsNew YorkUSA

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