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The Use and Abuse of Antibiotics and the Development of Antibiotic Resistance

  • B. Keith English
  • Aditya H. Gaur
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 659)

Abstract

The growing problem of antibiotic resistance has made the formerly routine therapy of many infectious diseases challenging, and, in rare cases, impossible. The widespread nature of the problem has led some experts to speculate about a “post-antibiotic era.” Furthermore, though antibiotic resistance occurs in nature and is an inevitable consequence of even the most prudent antibiotic use, it is clear that our overuse and misuse of antibiotics is responsible for most of the recent increases in antibiotic resistance (McGowan, 1983; Austin et al., 1999; Arnold and Straus, 2005). Judicious and rational antibiotic use has the potential to limit the emergence of clinically important antibiotic resistance and may be able to reduce the impact of resistance that has already developed, effectively prolonging the shelf life of today’s (and tomorrow’s) antibiotics (Dowell et al., 1988). Nonetheless, the threat posed by antibiotic-resistant pathogens has been a wakeup call for modern medicine – developing new antibiotics is important but strategies to prevent infectious diseases (by immunization or other public health measures) will always be preferable when feasible.

Keywords

Antibiotic Resistance Antimicrobial Resistance Antibiotic Exposure Pneumococcal Carriage Resistant Pneumococcus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.The University of Tennessee Health Science CenterMemphisUSA
  2. 2.Department of Infectious DiseasesSt. Jude Children’s Research HospitalMemphisUSA

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