Skip to main content
SpringerLink
Log in

Adenovirus Infection in the Immunocompromised Host

  • Chapter
  • First Online:
Hot Topics in Infection and Immunity in Children VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 659))

Abstract

There are 51 known serotypes of human adenovirus, which are divided into subgroups (or species) A to F Table ). An additional serotype (52), which potentially constitutes a new species (G), has recently been reported after genomic sequencing and phylogenetic analysis of an isolate in the U.S.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adeyemia, O.A., Yeldandi, A.V., & Ison, M.G. (2008). Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literature. AIDS Read, (18), 196–198, 201–202, 206–207.

    Google Scholar 

  • Adeyi, O.A., Randhawa, P.A., Nalesnik, M.A., Ochoa, E.R., Abu-Elmagd, K.M., Demetris, A.J., & Wu, T. (2008). Posttransplant adenoviral enteropathy in patients with small bowel transplantation. Arch Pathol Lab Med, (132), 703–705.

    PubMed  Google Scholar 

  • Adrian, T., Schafer, G., Cooney, M.K., Fox, J.P., & Wigand, R. (1988). Persistent enteral infections with adenovirus types 1 and 2 in infants: no evidence of reinfection. Epidemiol Infect, (101), 503–509.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, E.J., Guzman-Cottrill, J.A., Kletzel, M., Thormann, K., Sullivan, C., Zheng, X., & Katz, B.Z. (2008). High-risk adenovirus-infected pediatric allogenic hematopoietic progenitor transplant recipients and preemptive cidofovir therapy. Pediatr Transplant, (12), 219–227.

    Article  PubMed  CAS  Google Scholar 

  • Ardehali, H., Volmar, K., Roberts, C., Forman, M., & Becker, L.C. (2001). Fatal disseminated adenoviral infection in a renal transplant patient. Transplantation, (71), 998–999.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, A., Kingman, H., Darville, M., Foot, A.B., Grier, D., Cornish, J.M., Goulden, N. et al. (2001). Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant, (26), 1333–1338.

    Article  Google Scholar 

  • Bateman, C.M., Kesson, A.M., & Shaw, P.J. (2006). Pancreatitis and adenoviral infection in children after blood and marrow transplantation. Bone Marrow Transplant, (38), 807–811.

    Article  PubMed  CAS  Google Scholar 

  • Bergelson, J.M., Cunningham, J.A., Droguett, G., Kurt-Jones, E.A., Krithivas, A., Hong, J.S., Horwitz, M.S. et al. (1997). Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science, (275), 1320–1323.

    Article  PubMed  CAS  Google Scholar 

  • Berho, M., Torroella, M., Viciana, A., Weppler, D., Thompson, J., Nery, J., Tzakis, A., & Ruiz, P. (1998). Adenovirus enterocolitis in human small bowel transplants. Pediatr Transplant, (2), 277–282.

    PubMed  CAS  Google Scholar 

  • Bordigoni, P., Carret, A.S., Venard, V., Witz, F., & Le Faou, A. (2001). Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis, (32), 1290–1297.

    Article  PubMed  CAS  Google Scholar 

  • Bruno, B., Gooley, T., Hackman, R.C., Davis, C., Corey, L., & Boeckh, M. (2003). Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant, (9), 341–352.

    Article  PubMed  Google Scholar 

  • Cames, B., Rahier, J., Burtomboy, G., de Ville de Goyet, J., Reding, R., Lamy, M., Otte, J.B., & Sokal, E.M. (1992). Acute adenovirus hepatitis in liver transplant recipients. J Pediatr, (120), 33–37.

    Google Scholar 

  • Carter, B.A., Karpen, S.J., Quiros-Tejeira, R.E., Chang, I.F., Clark, B.S., Demmler, G.J., Heslop, H.E. et al. (2002). Intravenous Cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation, (74), 1050–1052.

    Article  PubMed  CAS  Google Scholar 

  • Cassano, W.F. (1991). Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (7), 247–248.

    PubMed  CAS  Google Scholar 

  • CDC. (2007). Acute respiratory disease associated with adenovirus serotype 14 – four states, 2006–2007. MMWR Morb Mortal Wkly Rep, (56), 1181–1184.

    Google Scholar 

  • Chakrabarti, S., Collingham, K.E., Fegan, C.D., & Milligan, D.W. (1999). Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant, (23), 1209–1211.

    Article  PubMed  CAS  Google Scholar 

  • Chakrabarti, S., Mautner, V., Osman, H., Collingham, K.E., Fegan, C.D., Klapper, P.E., Moss, P.A. et al. (2002). Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood, (100), 1619–1627.

    Article  PubMed  CAS  Google Scholar 

  • Claas, E.C., Schilham, M.W., de Brouwer, C.S., Hubacek, P., Echavarria, M., Lankester, A.C., van Tol, M.J. et al. (2005). Internally controlled real-time PCR monitoring of adenovirus DNA load in serum or plasma of transplant recipients. J Clin Microbiol, (43), 1738–1744.

    Article  PubMed  CAS  Google Scholar 

  • Dagan, R., Schwartz, R.H., Insel, R.A., & Menegus, M.A. (1984). Severe diffuse adenovirus 7a pneumonia in a child with combined immunodeficiency: possible therapeutic effect of human immune serum globulin containing specific neutralizing antibody. Pediatr Infect Dis, (3), 246–251.

    Article  PubMed  CAS  Google Scholar 

  • De Clercq, E. (2003). Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin Microbiol Rev, (16), 569–596.

    Article  PubMed  CAS  Google Scholar 

  • De Clercq, E., Andrei, G., Balzarini, J., Leyssen, P., Naesens, L., Neyts, J., Pannecouque, C. et al. (2005). Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. Nucleosides Nucleotides Nucleic Acids, (24), 331–341.

    Article  PubMed  CAS  Google Scholar 

  • de Mezerville, M.H., Tellier, R., Richardson, S., Hebert, D., Doyle, J., & Allen, U. (2006). Adenoviral infections in pediatric transplant recipients: a hospital-based study. Pediatr Infect Dis J, (25), 815–818.

    Article  PubMed  Google Scholar 

  • de Oliveira, C.B., Stevenson, D., LaBree, L., McDonnell, P.J., & Trousdale, M.D. (1996). Evaluation of Cidofovir (HPMPC, GS-504) against adenovirus type 5 infection in vitro and in a New Zealand rabbit ocular model. Antiviral Res, (31), 165–172.

    Article  PubMed  Google Scholar 

  • Doan, M.L., Mallory, G.B., Kaplan, S.L., Dishop, M.K., Schecter, M.G., McKenzie, E.D., Heinle, J.S. et al. (2007). Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients. J Heart Lung Transplant, (26), 883–889.

    Article  PubMed  Google Scholar 

  • Echavarria, M., Forman, M., Ticehurst, J., Dumler, J.S., & Charache, P. (1998). PCR method for detection of adenovirus in urine of healthy and human immunodeficiency virus-infected individuals. J Clin Microbiol, (36), 3323–3326.

    PubMed  CAS  Google Scholar 

  • Echavarria, M., Forman, M., van Tol, M.J., Vossen, J.M., Charache, P., & Kroes, A.C. (2001). Prediction of severe disseminated adenovirus infection by serum PCR. Lancet, (358), 384–385.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, K.M., Thompson, J., Paolini, J., & Wright, P.F. (1985). Adenovirus infections in young children. Pediatrics, (76), 420–424.

    PubMed  CAS  Google Scholar 

  • El-Sayed Zaki, M. & Abd-El Fatah, G.A. (2008). Rapid detection of oculopathogenic adenovirus in conjunctivitis. Curr Microbiol, (56), 105–109.

    Article  PubMed  CAS  Google Scholar 

  • Emovon, O.E., Lin, A., Howell, D.N., Afzal, F., Baillie, M., Rogers, J., Baliga, P. et al. (2003). Refractory adenovirus infection after simultaneous kidney-pancreas transplantation: successful treatment with intravenous ribavirin and pooled human intravenous immunoglobulin. Nephrol Dial Transplant, (18), 2436–2438.

    Article  PubMed  CAS  Google Scholar 

  • Erard, V., Huang, M.L., Ferrenberg, J., Nguy, L., Stevens-Ayers, T.L., Hackman, R.C., Corey, L. et al. (2007). Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: viral load as a marker for invasive disease. Clin Infect Dis, (45), 958–965.

    Article  PubMed  CAS  Google Scholar 

  • Espy, M.J., Hierholzer, J.C., & Smith, T.F. (1987). The effect of centrifugation on the rapid detection of adenovirus in shell vials. Am J Clin Pathol, (88), 358–360.

    PubMed  CAS  Google Scholar 

  • Feuchtinger, T., Lang, P., & Handgretinger, R. (2007). Adenovirus infection after allogeneic stem cell transplantation. Leuk Lymphoma, (48), 244–255.

    Article  PubMed  CAS  Google Scholar 

  • Feuchtinger, T., Matthes-Martin, S., Richard, C., Lion, T., Fuhrer, M., Hamprecht, K., Handgretinger, R., Peters, C. et al. (2006). Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol, (134), 64–76.

    Article  PubMed  Google Scholar 

  • Fianchi, L., Scardocci, A., Cattani, P., Tartaglione, T., & Pagano, L. (2003). Adenovirus meningoencephalitis in a patient with large B-cell lymphoma. Ann Hematol, (82), 313–315.

    PubMed  CAS  Google Scholar 

  • Flomenberg, P., Babbitt, J., Drobyski, W.R., Ash, R.C., Carrigan, D.R., Sedmak, G.V., McAuliffe, T. et al. (1994). Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis, (169), 775–781.

    PubMed  CAS  Google Scholar 

  • Fox, J.P., Brandt, C.D., Wassermann, F.E., Hall, C.E., Spigland, I., Kogon, A., & Elveback, L.R. (1969). The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VI. Observations of adenovirus infections: virus excretion patterns, antibody response, efficiency of surveillance, patterns of infections, and relation to illness. Am J Epidemiol, (89), 25–50.

    PubMed  CAS  Google Scholar 

  • Freymuth, F., Vabret, A., Cuvillon-Nimal, D., Simon, S., Dina, J., Legrand, L., Gouarin, S. et al. (2006). Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol, (78), 1498–1504.

    Article  PubMed  CAS  Google Scholar 

  • Gardner, P.S. (1968). Virus infections and respiratory disease of childhood. Arch Dis Child, (43), 629–645.

    Article  PubMed  CAS  Google Scholar 

  • Garnett, C.T., Erdman, D., Xu, W., & Gooding, L.R. (2002). Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. J Virol, (76), 10608–10616.

    Article  PubMed  CAS  Google Scholar 

  • Greber, U.F., Suomalainen, M., Stidwill, R.P., Boucke, K., Ebersold, M.W., & Helenius, A. (1997). The role of the nuclear pore complex in adenovirus DNA entry. Embo J, (16), 5998–6007.

    Article  PubMed  CAS  Google Scholar 

  • Greber, U.F., Willetts, M., Webster, P., & Helenius, A. (1993). Stepwise dismantling of adenovirus 2 during entry into cells. Cell, (75), 477–486.

    Article  PubMed  CAS  Google Scholar 

  • Hale, G.A., Heslop, H.E., Krance, R.A., Brenner, M.A., Jayawardene, D., Srivastava, D.K., & Patrick, C.C. (1999). Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant, (23), 277–282.

    Article  PubMed  CAS  Google Scholar 

  • Hatakeyama, N., Suzuki, N., Kudoh, T., Hori, T., Mizue, N., & Tsutsumi, H. (2003). Successful cidofovir treatment of adenovirus-associated hemorrhagic cystitis and renal dysfunction after allogenic bone marrow transplant. Pediatr Infect Dis J, (22), 928–929.

    Article  PubMed  Google Scholar 

  • Hedderwick, S.A., Greenson, J.K., McGaughy, V.R., & Clark, N.M. (1998). Adenovirus cholecystitis in a patient with AIDS. Clin Infect Dis, (26), 997–999.

    Article  PubMed  CAS  Google Scholar 

  • Heemskerk, B., Lankester, A.C., van Vreeswijk, T., Beersma, M.F., Claas, E.C., Veltrop-Duits, L.A., Kroes, A.C. et al. (2005). Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients. J Infect Dis, (191), 520–530.

    Article  PubMed  CAS  Google Scholar 

  • Hierholzer, J.C. (1992). Adenoviruses in the immunocompromised host. Clin Microbiol Rev, (5), 262–274.

    PubMed  CAS  Google Scholar 

  • Hillenkamp, J., Reinhard, T., Ross, R.S., Bohringer, D., Cartsburg, O., Roggendorf, M., De Clercq, E. et al. (2001). Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study. Arch Ophthalmol, (119), 1487–1491.

    PubMed  CAS  Google Scholar 

  • Hillenkamp, J., Reinhard, T., Ross, R.S., Bohringer, D., Cartsburg, O., Roggendorf, M., De Clercq, E. et al. (2002). The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study. Ophthalmology, (109), 845–850.

    Article  PubMed  Google Scholar 

  • Hoffman, J.A. (2006). Adenoviral disease in pediatric solid organ transplant recipients. Pediatr Transplant, (10), 17–25.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, J.A., Shah, A.J., Ross, L.A., & Kapoor, N. (2001). Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, (7), 388–394.

    Article  PubMed  CAS  Google Scholar 

  • Hofland, C.A., Eron, L.J., & Washecka, R.M. (2004). Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc, (36), 3025–3027.

    Article  PubMed  CAS  Google Scholar 

  • Hong, J.Y., Lee, H.J., Piedra, P.A., Choi, E.H., Park, K.H., Koh, Y.Y., & Kim, W.S. (2001). Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis. Clin Infect Dis, (32), 1423–1429.

    Article  PubMed  CAS  Google Scholar 

  • Hough, R., Chetwood, A., Sinfield, R., Welch, J., & Vora, A. (2005). Fatal adenovirus hepatitis during standard chemotherapy for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol, (27), 67–72.

    Article  PubMed  Google Scholar 

  • Howard, D.S., Phillips, I.G., Reece, D.E., Munn, R.K., Henslee-Downey, J., Pittard, M., Barker, M. et al. (1999). Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis, (29), 1494–1501.

    Article  PubMed  CAS  Google Scholar 

  • Hromas, R., Clark, C., Blanke, C., Tricot, G., Cornetta, K., Hedderman, A., & Broun, E.R. (1994a). Failure of ribavirin to clear adenovirus infections in T cell-depleted allogeneic bone marrow transplantation. Bone Marrow Transplant, (14), 663–664.

    PubMed  CAS  Google Scholar 

  • Hromas, R., Cornetta, K., Srour, E., Blanke, C., & Broun, E.R. (1994b). Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation. Blood, (84), 1689–1690.

    PubMed  CAS  Google Scholar 

  • Humar, A., Kumar, D., Mazzulli, T., Razonable, R.R., Moussa, G., Paya, C.V., Covington, E. et al. (2005). A surveillance study of adenovirus infection in adult solid organ transplant recipients. Am J Transplant, (5), 2555–2559.

    Article  PubMed  Google Scholar 

  • Ison, M.G. (2006). Adenovirus infections in transplant recipients. Clin Infect Dis, (43), 331–339.

    Article  PubMed  Google Scholar 

  • Jones, M.S., 2nd, Harrach, B., Ganac, R.D., Gozum, M.M., Dela Cruz, W.P., Riedel, B., Pan, C. et al (2007). New adenovirus species found in a patient presenting with gastroenteritis. J Virol, (81), 5978–5984.

    Article  PubMed  CAS  Google Scholar 

  • Kalpoe, J.S., van der Heiden, P.L., Barge, R.M., Houtzager, S., Lankester, A.C., van Tol, M.J., & Kroes, A.C. (2007). Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning. Eur J Haematol, (78), 314–321.

    Article  PubMed  CAS  Google Scholar 

  • Kampmann, B., Cubitt, D., Walls, T., Naik, P., Depala, M., Samarasinghe, S., Robson, D., Hassan, A. et al. (2005). Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol, (130), 595–603.

    Article  PubMed  CAS  Google Scholar 

  • Kawakami, M., Ueda, S., Maeda, T., Karasuno, T., Teshima, H., Hiraoka, A., Nakamura, H. et al. (1997). Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (20), 485–490.

    Article  PubMed  CAS  Google Scholar 

  • Keswani, M. & Moudgil, A. (2007). Adenovirus-associated hemorrhagic cystitis in a pediatric renal transplant recipient. Pediatr Transplant, (11), 568–571.

    Article  PubMed  Google Scholar 

  • Kim, M.R., Lee, H.R., & Lee, G.M. (2000). Epidemiology of acute viral respiratory tract infections in Korean children. J Infect, (41), 152–158.

    Article  PubMed  CAS  Google Scholar 

  • Kinchington, P.R., Araullo-Cruz, T., Vergnes, J.P., Yates, K., & Gordon, Y.J. (2002). Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir. Antiviral Res, (56), 73–84.

    Article  PubMed  CAS  Google Scholar 

  • Kitabayashi, A., Hirokawa, M., Kuroki, J., Nishinari, T., Niitsu, H., & Miura, A.B. (1994). Successful vidarabine therapy for adenovirus type 11-associated acute hemorrhagic cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (14), 853–854.

    PubMed  CAS  Google Scholar 

  • Kojaoghlanian, T., Flomenberg, P., & Horwitz, M.S. (2003). The impact of adenovirus infection on the immunocompromised host. Rev Med Virol, (13), 155–171.

    Article  PubMed  Google Scholar 

  • Koneru, B., Jaffe, R., Esquivel, C.O., Kunz, R., Todo, S., Iwatsuki, S., & Starzl, T.E. (1987). Adenoviral infections in pediatric liver transplant recipients. Jama, (258), 489–492.

    PubMed  CAS  Google Scholar 

  • Kurosaki, K., Miwa, N., Yoshida, Y., Kurokawa, M., Kurimoto, M., Endo, S., & Shiraki, K. (2004). Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother, (15), 281–285.

    PubMed  CAS  Google Scholar 

  • La Rosa, A.M., Champlin, R.E., Mirza, N., Gajewski, J., Giralt, S., Rolston, K.V., Raad, I. et al. (2001). Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis, (32), 871–876.

    Article  PubMed  Google Scholar 

  • Lankester, A.C., Heemskerk, B., Claas, E.C., Schilham, M.W., Beersma, M.F., Bredius, R.G., van Tol, M.J. et al. (2004). Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin Infect Dis, (38), 1521–1525.

    Article  PubMed  CAS  Google Scholar 

  • Lankester, A.C., van Tol, M.J., Claas, E.C., Vossen, J.M., & Kroes, A.C. (2002). Quantification of adenovirus DNA in plasma for management of infection in stem cell graft recipients. Clin Infect Dis, (34), 864–867.

    Article  PubMed  CAS  Google Scholar 

  • Leen, A.M., Myers, G.D., Bollard, C.M., Huls, M.H., Sili, U., Gee, A.P., Heslop, H.E. et al. (2005). T-cell immunotherapy for adenoviral infections of stem-cell transplant recipients. Ann N Y Acad Sci, (1062), 104–115.

    Article  PubMed  CAS  Google Scholar 

  • Leen, A.M., Myers, G.D., Sili, U., Huls, M.H., Weiss, H., Leung, K.S., Carrum, G. et al. (2006). Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med, (12), 1160–1166.

    Article  PubMed  CAS  Google Scholar 

  • Lenaerts, L., Verbeken, E., De Clercq, E., & Naesens, L. (2005). Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections. Antimicrob Agents Chemother, (49), 4689–4699.

    Article  PubMed  CAS  Google Scholar 

  • Leruez-Ville, M., Chardin-Ouachee, M., Neven, B., Picard, C., Le Guinche, I., Fischer, A., Rouzioux, C. et al. (2006). Description of an adenovirus A31 outbreak in a paediatric haematology unit. Bone Marrow Transplant, (38), 23–28.

    Article  PubMed  CAS  Google Scholar 

  • Leruez-Ville, M., Minard, V., Lacaille, F., Buzyn, A., Abachin, E., Blanche, S., Freymuth, F. et al. (2004). Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis, (38), 45–52.

    Article  PubMed  CAS  Google Scholar 

  • Leung, A.Y., Chan, M., Cheng, V.C., Yuen, K.Y., & Kwong, Y.L. (2005). Quantification of adenovirus in the lower respiratory tract of patients without clinical adenovirus-related respiratory disease. Clin Infect Dis, (40), 1541–1544.

    Article  PubMed  Google Scholar 

  • Liles, W.C., Cushing, H., Holt, S., Bryan, C., & Hackman, R.C. (1993). Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. Bone Marrow Transplant, (12), 409–412.

    PubMed  CAS  Google Scholar 

  • Lion, T., Baumgartinger, R., Watzinger, F., Matthes-Martin, S., Suda, M., Preuner, S., Futterknecht, B. et al. (2003). Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood, (102), 1114–1120.

    Article  PubMed  CAS  Google Scholar 

  • Ljungman, P., Ribaud, P., Eyrich, M., Matthes-Martin, S., Einsele, H., Bleakley, M., Machaczka, M. et al. (2003). Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant, (31), 481–486.

    Article  PubMed  CAS  Google Scholar 

  • Louie, J.K., Kajon, A.E., Holodniy, M., Guardia-LaBar, L., Lee, B., Petru, A.M., Hacker, J.K. et al. (2008). Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? Clin Infect Dis, (46), 421–425.

    Article  PubMed  CAS  Google Scholar 

  • Mahafzah, A.M. & Landry, M.L. (1989). Evaluation of immunofluorescent reagents, centrifugation, and conventional cultures for the diagnosis of adenovirus infection. Diagn Microbiol Infect Dis, (12), 407–411.

    Article  PubMed  CAS  Google Scholar 

  • Mann, D., Moreb, J., Smith, S., & Gian, V. (1998). Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report. J Infect, (36), 227–228.

    Google Scholar 

  • Maslo, C., Girard, P.M., Urban, T., Guessant, S., & Rozenbaum, W. (1997). Ribavirin therapy for adenovirus pneumonia in an AIDS patient. Am J Respir Crit Care Med, (156), 1263–1264.

    PubMed  CAS  Google Scholar 

  • Matar, L.D., McAdams, H.P., Palmer, S.M., Howell, D.N., Henshaw, N.G., Davis, R.D., & Tapson, V.F. (1999). Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation. Radiology, (213), 735–742.

    PubMed  CAS  Google Scholar 

  • McGrath, D., Falagas, M.E., Freeman, R., Rohrer, R., Fairchild, R., Colbach, C., & Snydman, D.R. (1998). Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis, (177), 459–462.

    Article  PubMed  CAS  Google Scholar 

  • Medina-Kauwe, L.K. (2003). Endocytosis of adenovirus and adenovirus capsid proteins. Adv Drug Deliv Rev, (55), 1485–1496.

    Article  PubMed  CAS  Google Scholar 

  • Mentel, R., Kinder, M., Wegner, U., von Janta-Lipinski, M., & Matthes, E. (1997). Inhibitory activity of 3’-fluoro-2’ deoxythymidine and related nucleoside analogues against adenoviruses in vitro. Antiviral Res, (34), 113–119.

    Article  PubMed  CAS  Google Scholar 

  • Mentel, R. & Wegner, U. (2000). Evaluation of the efficacy of 2’,3’-dideoxycytidine against adenovirus infection in a mouse pneumonia model. Antiviral Res, (47), 79–87.

    Article  PubMed  CAS  Google Scholar 

  • Michaels, M.G., Green, M., Wald, E.R., & Starzl, T.E. (1992). Adenovirus infection in pediatric liver transplant recipients. J Infect Dis, (165), 170–174.

    PubMed  CAS  Google Scholar 

  • Morfin, F., Dupuis-Girod, S., Mundweiler, S., Falcon, D., Carrington, D., Sedlacek, P., Bierings, M. et al. (2005). In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther, (10), 225–229.

    PubMed  CAS  Google Scholar 

  • Muller, W.J., Levin, M.J., Shin, Y.K., Robinson, C., Quinones, R., Malcolm, J., Hild, E. et al. (2005). Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. Clin Infect Dis, (41), 1812–1816.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, G.F., Wood, D.P., Jr., McRoberts, J.W., & Henslee-Downey, P.J. (1993). Adenovirus-associated hemorrhagic cystitis treated with intravenous ribavirin. J Urol, (149), 565–566.

    PubMed  CAS  Google Scholar 

  • Myerowitz, R.L., Stalder, H., Oxman, M.N., Levin, M.J., Moore, M., Leith, J.D., Gantz, N.M. et al. (1975). Fatal disseminated adenovirus infection in a renal transplant recipient. Am J Med, (59), 591–598.

    Article  PubMed  CAS  Google Scholar 

  • Naesens, L., Lenaerts, L., Andrei, G., Snoeck, R., Van Beers, D., Holy, A., Balzarini, J. et al. (2005). Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrob Agents Chemother, (49), 1010–1016.

    Article  PubMed  CAS  Google Scholar 

  • Nagafuji, K., Aoki, K., Henzan, H., Kato, K., Miyamoto, T., Eto, T., Nagatoshi, Y. et al. (2004). Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients. Bone Marrow Transplant, (34), 909–914.

    Article  PubMed  CAS  Google Scholar 

  • Nebbia, G., Chawla, A., Schutten, M., Atkinson, C., Raza, M., Johnson, M., & Geretti, A. (2005). Adenovirus viraemia and dissemination unresponsive to antiviral therapy in advanced HIV-1 infection. Aids, (19), 1339–1340.

    Article  PubMed  CAS  Google Scholar 

  • Nemerow, G.R., Cheresh, D.A., & Wickham, T.J. (1994). Adenovirus entry into host cells: a role for alpha(v) integrins. Trends Cell Biol, (4), 52–55.

    Article  PubMed  CAS  Google Scholar 

  • Neofytos, D., Ojha, A., Mookerjee, B., Wagner, J., Filicko, J., Ferber, A., Dessain, S. et al. (2007). Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transplant, (13), 74–81.

    Article  PubMed  CAS  Google Scholar 

  • Pacini, D.L., Collier, A.M., & Henderson, F.W. (1987). Adenovirus infections and respiratory illnesses in children in group day care. J Infect Dis, (156), 920–927.

    PubMed  CAS  Google Scholar 

  • Palmer, S.M., Jr., Henshaw, N.G., Howell, D.N., Miller, S.E., Davis, R.D., & Tapson, V.F. (1998). Community respiratory viral infection in adult lung transplant recipients. Chest, (113), 944–950.

    Article  PubMed  Google Scholar 

  • Parizhskaya, M., Walpusk, J., Mazariegos, G., & Jaffe, R. (2001). Enteric adenovirus infection in pediatric small bowel transplant recipients. Pediatr Dev Pathol, (4), 122–128.

    Article  PubMed  CAS  Google Scholar 

  • Pinchoff, R.J., Kaufman, S.S., Magid, M.S., Erdman, D.D., Gondolesi, G.E., Mendelson, M.H., Tane, K. et al. (2003). Adenovirus infection in pediatric small bowel transplantation recipients. Transplantation, (76), 183–189.

    Article  PubMed  Google Scholar 

  • Rocholl, C., Gerber, K., Daly, J., Pavia, A.T., & Byington, C.L. (2004). Adenoviral infections in children: the impact of rapid diagnosis. Pediatrics, (113), e51–e56.

    Article  PubMed  Google Scholar 

  • Romanowski, E.G., Yates, K.A., & Gordon, Y.J. (2001). Antiviral prophylaxis with twice daily topical cidofovir protects against challenge in the adenovirus type 5/New Zealand rabbit ocular model. Antiviral Res, (52), 275–280.

    Article  PubMed  CAS  Google Scholar 

  • Rosario, R.F., Kimbrough, R.C., Van Buren, D.H., & Laski, M.E. (2006). Fatal adenovirus serotype-5 in a deceased-donor renal transplant recipient. Transpl Infect Dis, (8), 54–57.

    Article  PubMed  CAS  Google Scholar 

  • Runde, V., Ross, S., Trenschel, R., Lagemann, E., Basu, O., Renzing-Kohler, K., Schaefer, U.W. et al. (2001). Adenoviral infection after allogeneic stem cell transplantation (SCT): report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study. Bone Marrow Transplant, (28), 51–57.

    Google Scholar 

  • Sabroe, I., McHale, J., Tait, D.R., Lynn, W.A., Ward, K.N., & Shaunak, S. (1995). Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin. Thorax, (50), 1219–1220.

    Article  PubMed  CAS  Google Scholar 

  • Safrin, S., Cherrington, J., & Jaffe, H.S. (1997). Clinical uses of cidofovir. Rev Med Virol, (7), 145–156.

    Article  PubMed  CAS  Google Scholar 

  • Schilham, M.W., Claas, E.C., van Zaane, W., Heemskerk, B., Vossen, J.M., Lankester, A.C., Toes, R.E. et al. (2002). High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis, (35), 526–532.

    Article  PubMed  Google Scholar 

  • Schowengerdt, K.O., Ni, J., Denfield, S.W., Gajarski, R.J., Radovancevic, B., Frazier, H.O., Demmler, G.J. et al. (1996). Diagnosis, surveillance, and epidemiologic evaluation of viral infections in pediatric cardiac transplant recipients with the use of the polymerase chain reaction. J Heart Lung Transplant, (15), 111–123.

    PubMed  CAS  Google Scholar 

  • Seidel, M.G., Kastner, U., Minkov, M., & Gadner, H. (2003). IVIG treatment of adenovirus infection-associated macrophage activation syndrome in a two-year-old boy: case report and review of the literature. Pediatr Hematol Oncol, (20), 445–451.

    Google Scholar 

  • Seidemann, K., Heim, A., Pfister, E.D., Koditz, H., Beilken, A., Sander, A., Melter, M. et al. (2004). Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature. Am J Transplant, (4), 2102–2108.

    Google Scholar 

  • Seth, P. (1994). Adenovirus-dependent release of choline from plasma membrane vesicles at an acidic pH is mediated by the penton base protein. J Virol, (68), 1204–1206.

    PubMed  CAS  Google Scholar 

  • Shields, A.F., Hackman, R.C., Fife, K.H., Corey, L., & Meyers, J.D. (1985). Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med, (312), 529–533.

    Article  PubMed  CAS  Google Scholar 

  • Shirali, G.S., Ni, J., Chinnock, R.E., Johnston, J.K., Rosenthal, G.L., Bowles, N.E., & Towbin, J.A. (2001). Association of viral genome with graft loss in children after cardiac transplantation. N Engl J Med, (344), 1498–1503.

    Article  PubMed  CAS  Google Scholar 

  • Sivaprakasam, P., Carr, T.F., Coussons, M., Khalid, T., Bailey, A.S., Guiver, M., Mutton, K.J. et al. (2007). Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention. J Pediatr Hematol Oncol, (29), 81–85.

    Article  PubMed  Google Scholar 

  • Steiner, I., Aebi, C., Ridolfi Luthy, A., Wagner, B., & Leibundgut, K. (2008). Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer, (50), 647–649.

    Article  PubMed  Google Scholar 

  • Symeonidis, N., Jakubowski, A., Pierre-Louis, S., Jaffe, D., Pamer, E., Sepkowitz, K., O’Reilly, R.J. et al. (2007). Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transpl Infect Dis, (9), 108–113.

    Article  PubMed  CAS  Google Scholar 

  • Uchio, E., Fuchigami, A., Kadonosono, K., Hayashi, A., Ishiko, H., Aoki, K., & Ohno, S. (2007). Anti-adenoviral effect of anti-HIV agents in vitro in serotypes inducing keratoconjunctivitis. Graefes Arch Clin Exp Ophthalmol, (245), 1319–1325.

    Article  PubMed  CAS  Google Scholar 

  • van Tol, M.J., Kroes, A.C., Schinkel, J., Dinkelaar, W., Claas, E.C., Jol-van der Zijde, C.M. et al. (2005). Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery. Bone Marrow Transplant, (36), 39–50.

    Article  PubMed  Google Scholar 

  • Wallot, M.A., Dohna-Schwake, C., Auth, M., Nadalin, S., Fiedler, M., Malago, M., Broelsch, C. et al. (2006). Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: impact of intravenous cidofovir and inhaled nitric oxide. Pediatr Transplant, (10), 121–127.

    Article  PubMed  CAS  Google Scholar 

  • Walls, T., Hawrami, K., Ushiro-Lumb, I., Shingadia, D., Saha, V., & Shankar, A.G. (2005). Adenovirus infection after pediatric bone marrow transplantation: is treatment always necessary? Clin Infect Dis, (40), 1244–1249.

    Article  PubMed  Google Scholar 

  • Walls, T., Shankar, A.G., & Shingadia, D. (2003). Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients. Lancet Infect Dis, (3), 79–86.

    Article  PubMed  Google Scholar 

  • Wickham, T.J., Mathias, P., Cheresh, D.A., & Nemerow, G.R. (1993). Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell, (73), 309–319.

    Article  PubMed  CAS  Google Scholar 

  • Wigger, H.J. & Blanc, W.A. (1966). Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. N Engl J Med, (275), 870–874.

    Article  PubMed  CAS  Google Scholar 

  • Wong, S., Pabbaraju, K., Pang, X.L., Lee, B.E., & Fox, J.D. (2008). Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol, (80), 856–865.

    Article  PubMed  CAS  Google Scholar 

  • Wulffraat, N.M., Geelen, S.P., van Dijken, P.J., de Graeff-Meeder, B., Kuis, W., & Boven, K. (1995). Recovery from adenovirus pneumonia in a severe combined immunodeficiency patient treated with intravenous ribavirin. Transplantation, (59), 927.

    PubMed  CAS  Google Scholar 

  • Yusuf, U., Hale, G.A., Carr, J., Gu, Z., Benaim, E., Woodard, P., Kasow, K.A. et al. (2006). Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation, (81), 1398–1404.

    Article  PubMed  CAS  Google Scholar 

  • Ziring, D., Tran, R., Edelstein, S., McDiarmid, S.V., Gajjar, N., Cortina, G., Vargas, J. et al. (2005). Infectious enteritis after intestinal transplantation: incidence, timing, and outcome. Transplantation, (79), 702–709.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatrics, Department of General Medicine; Microbiology & Infectious Diseases Research Group, Murdoch Children’s Research Institute: Infectious Diseases Unit, The University of Melbourne; Royal Children’s Hospital Melbourne, 3052, Parkville, VIC, Australia

    Marc Tebruegge & Nigel Curtis

Authors
  1. Marc Tebruegge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nigel Curtis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nigel Curtis .

Editor information

Editors and Affiliations

  1. Institute of Child Life and Health, University of Bristol, Upper Maudlin Street, Bristol, BS2 8AE, United Kingdom

    Adam Finn

  2. Royal Children's Hosp., University of Melbourne, Parkville , 3052, Australia

    Nigel Curtis

  3. University of Oxford, Level 4,John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom

    Andrew J. Pollard

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Tebruegge, M., Curtis, N. (2010). Adenovirus Infection in the Immunocompromised Host. In: Finn, A., Curtis, N., Pollard, A. (eds) Hot Topics in Infection and Immunity in Children VI. Advances in Experimental Medicine and Biology, vol 659. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0981-7_13

Download citation

Publish with us

Policies and ethics

Search

Navigation