Advertisement

Pediatric Abdominal Tumors: Wilms Tumor

  • Marilyn J. Siegel
Chapter

Key Points

■ The clinical presentation of Wilms tumor is usually by palpation of a non-tender abdominal mass but can be nonspecific and sometimes confusing (strong evidence).

■ Features that need to be evaluated on imaging studies for surgical planning or staging in patients with Wilms tumor are the presence of vascular invasion, regional lymph node enlargement, contralateral tumors, and lung or liver metastases (strong evidence).

■ Ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) have high sensitivity for tumor detection and moderate specificity (limited evidence).

■ CT and MRI are superior to ultrasonography for detection of regional lymph node involvement and bilateral tumors (limited to moderate evidence).

■ CT is superior to chest radiography for detecting pulmonary metastases (moderate evidence).

■ Screening children with risk factors for development of Wilms tumor results in detection of early-stage tumors and is cost-effective (moderate to strong evidence).

Keywords

Pulmonary Metastasis Renal Vein Pulmonary Nodule Moderate Evidence Regional Lymph Node Involvement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bernstein L, Linet M, Smith MA, Olshan AF. In Ries LAG, Smith MA, Gurney JG (eds.). Cancer Incidence and Survival among Children and Adolescents: United States SEER Program, 1975–1995, National Cancer Institute, SEER Program. Bethesda, MD: NIH Publ. No. 99–4649, 1999; 99:79–90.Google Scholar
  2. 2.
    2.Brodeur AE, Brodeur GM. Pediatr Rev 1991; 12:196–206.CrossRefPubMedGoogle Scholar
  3. 3.
    Dome JS, Perlman EJ, Ritchey ML et al. In Pizzo PA, Poplack DG (eds.). Principles and Practice of Pediatric Oncology, 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2006; 905–932.Google Scholar
  4. 4.
    Husain AN, Pysher TJ, Dehner LP. In Stocker JT, Dehner LP (eds.). Pediatric Pathology, 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2001; 835–903.Google Scholar
  5. 5.
    Bove K, McAdams A. Prespect Pediatr Pathol 1976; 3:185–223.Google Scholar
  6. 6.
    Beckwith JB. Med Pediatr Oncol 1993; 21:158–168.CrossRefPubMedGoogle Scholar
  7. 7.
    Beckwith JB, Kiviat NB, Bonadio JF. Pediatr Pathol 1990; 10:1–36.CrossRefPubMedGoogle Scholar
  8. 8.
    Beckwith JB. Am J Med Genet 1998; 79:268–273.CrossRefPubMedGoogle Scholar
  9. 9.
    Gylys-Morin V, Hoffer FA, Kozakewich H et al.: Radiology 1993; 188:517–521.PubMedGoogle Scholar
  10. 10.
    Breslow N, Olshan A, Beckwith JB, Green DM. Med Pediatr Oncol 1993; 21:172–181.CrossRefPubMedGoogle Scholar
  11. 11.
    Stiller CA, Parkin DM. Br J Cancer 1990; 62:1026–1030.PubMedGoogle Scholar
  12. 12.
    Breslow NE, Olson J, Moksness J, Beckwith JB, Grundy P. Med Pediatr Oncol 1996; 27:398–403.CrossRefPubMedGoogle Scholar
  13. 13.
    Wiener JS, Coppes MJ, Ritchey ML. J Urol 1988; 159:1316–1325.CrossRefGoogle Scholar
  14. 14.
    Coppes MJ, Haber DA, Grundy PE. N Engl J Med 1994; 331:586–590.CrossRefPubMedGoogle Scholar
  15. 15.
    McNeil DE, Brown M, Ching A, DeBaun MR. Med Pediatr Oncol 2001 Oct; 37(4):349–356CrossRefPubMedGoogle Scholar
  16. 16.
    Beckwith JB. Pediatr Dev Pathol 1998; 1:79–84.CrossRefPubMedGoogle Scholar
  17. 17.
    Green DM. Eur J Cancer 1997; 33(3): 409–418.CrossRefPubMedGoogle Scholar
  18. 18.
    Green DM, Breslow NE, Beckwith JB et al. J Clin Oncol 1998; 16:237–245.PubMedGoogle Scholar
  19. 19.
    Green DM, Beckwith JB, Breslow NE et al. J Clin Oncol 1994; 12:2126–2131.PubMedGoogle Scholar
  20. 20.
    Navoy JE, Royal SA, Vaid YN, Mroczek-Musulman EC. Pediatr Radiol 1995; 25:S76–S86.PubMedGoogle Scholar
  21. 21.
    Andresen J, Steenskov V. Acta Radiol Diag 1981; 22:353–358Google Scholar
  22. 22.
    Tournade MF, Com-Nougue C, de Kraker J et al. J Clin Oncol 2001; 19:488–500.PubMedGoogle Scholar
  23. 23.
    Reiman TA, Siegel MJ, Shackelford GD. Radiology 1986; 160:501–505.PubMedGoogle Scholar
  24. 24.
    Belt TG, Cohen BD, Smith JA, Cory DA, McKenna S et al. 1986; 146:955–961.Google Scholar
  25. 25.
    Breslow NE, Palmer NF, Hill LR, Buring J, D‘Angio GJ. Cancer 1978; 41:1577–1589.CrossRefPubMedGoogle Scholar
  26. 26.
    Schmidt TY, Hohl C, Haage P et al. AJR 2003; 180:1639–1647PubMedGoogle Scholar
  27. 27.
    Breslow N, Churchill G, Beckwith JB et al. J Clin Oncol 1985; 3:521–531.PubMedGoogle Scholar
  28. 28.
    Weese DL, Applebaum H, Taber P. J Pediatr Surg 1991; 26:64–67.CrossRefPubMedGoogle Scholar
  29. 29.
    Breslow N, Sharples K, Beckwith JB et al. Cancer 1991; 68:2345–2353.CrossRefPubMedGoogle Scholar
  30. 30.
    Owens CM, Veys PA, Pritchard J, Levitt G et al. J Clin Oncol 2002; 20:2768–2773.CrossRefPubMedGoogle Scholar
  31. 31.
    Wootton-Gorges AL, Albano EA, Riggs JM et al. Pediatr Radiol 2000; 30:533–539.CrossRefPubMedGoogle Scholar
  32. 32.
    Meisel JA, Guthrie KA, Breslow NE, Donaldson SS, Green DM. Int J Radiat Oncol Biol Phys 1999 Jun 1; 44(3):579–585.CrossRefPubMedGoogle Scholar
  33. 33.
    Cohen MD. Clin Radiol 1993; 47:77–81.CrossRefPubMedGoogle Scholar
  34. 34.
    Ditchfield MR, DeCampo JF, Waters KD, Nolan TM. Med Pediatr Oncol 1995; 24:93–96.CrossRefPubMedGoogle Scholar
  35. 35.
    Hugosson C, Nyman R, Jacobsson B et al. Acta Radiol 36: Fasc 3, 1995; 254–260.Google Scholar
  36. 36.
    Ritchey ML, Green DM, Breslow NB, Moksness J, Norkool P. Cancer 1995; 75:600–604.CrossRefPubMedGoogle Scholar
  37. 37.
    Wilimas JA, Kaste SC, Kauffman WM et al. J Clin Oncol 1997; 15:2631–2635.PubMedGoogle Scholar
  38. 38.
    McCarville MB, Lederman HM, Santana VM et al. Radiology 2006; 239:514–520.CrossRefPubMedGoogle Scholar
  39. 39.
    Beckwith JB. AJR 1995; 164: 1294–1295.Google Scholar
  40. 40.
    Weng EY, Moeschler JB, Graham JM. AM J Med Genet 1995; 56:366–373.CrossRefPubMedGoogle Scholar
  41. 41.
    Choyke PL, Siegel MJ, Craft AW et al. Med Ped Oncol 1999;32: 196–200.CrossRefGoogle Scholar
  42. 42.
    Green D, Breslow N, Beckwith J et al. Med Pediatr Oncol 1993; 21:188–192.CrossRefPubMedGoogle Scholar
  43. 43.
    Porteus MH, Narkool P, Neuberg D et al. J Clin Oncol 2000; 18: 2026–2031.PubMedGoogle Scholar
  44. 44.
    Brisse HJ, Smets AM, Kaste SC, Owens CM. Pediatr Radiol 2008; 38:18–29.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Mallinckrodt Institute of RadiologyWashington University Medical SchoolSt. LouisUSA

Personalised recommendations