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The ‘Totality’ of Psychosis: Epidemiology and Developmental Pathobiology

  • Olabisi Owoeye
  • Tara Kingston
  • Robin J. Hennessy
  • Patrizia A. Baldwin
  • David Browne
  • Paul J. Scully
  • Anthony Kinsella
  • Vincent Russell
  • Eadbhard O’Callaghan
  • John L. Waddington
Chapter

Abstract

Among numerous impediments to further advancement between the fifth and sixth symposia on Search for the Causes of Schizophrenia, several uncertainties endure: (i) What are the boundaries of psychotic illness? (ii) Where do we position what we currently conceptualise and diagnose as schizophrenia within the much broader reality of psychotic disorder among those with serious mental illness and, indeed, of psychotic phenomena among the general population? (iii) To what extent are those components of psychotic illness that we resolve into separate diagnostic categories actually distinct in any fundamental way in terms of their epidemiological, clinical and pathobiological ‘signature’?

Keywords

Bipolar Disorder Major Depressive Disorder Psychotic Disorder Bipolar Patient Schizoaffective Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The Cavan–Monaghan First-Episode Study was supported initially by the Stanley Medical Research Institute and, subsequently, by Cavan–Monaghan Mental Health Service. Studies on the developmental pathobiology of psychosis are supported by Science Foundation Ireland. We thank the clinical teams and associated staff of Cavan–Monaghan Mental Health Service for their important contributions and Dr. Ronan Conroy, Department of Epidemiology, for assistance with incidence analyses.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Olabisi Owoeye
    • 1
    • 2
  • Tara Kingston
    • 1
    • 2
  • Robin J. Hennessy
    • 1
  • Patrizia A. Baldwin
    • 1
    • 2
  • David Browne
    • 1
    • 2
  • Paul J. Scully
    • 1
    • 2
  • Anthony Kinsella
    • 1
  • Vincent Russell
    • 2
    • 3
  • Eadbhard O’Callaghan
    • 4
  • John L. Waddington
    • 5
  1. 1.Molecular and Cellular Therapeutics, Royal College of Surgeons in IrelandDublinIreland
  2. 2.Cavan-Monaghan Mental Health Service, St. Davnet´s HospitalMonaghanIreland
  3. 3.Department of Psychiatry, Royal College of Surgeons in IrelandDublinIreland
  4. 4.DETECT Early Psychosis Service, Co.DublinIreland
  5. 5.Molecular & Cellular Therapeutics, Royal College of Surgeons in IrelandDublin 2Ireland

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