The ‘Totality’ of Psychosis: Epidemiology and Developmental Pathobiology
Among numerous impediments to further advancement between the fifth and sixth symposia on Search for the Causes of Schizophrenia, several uncertainties endure: (i) What are the boundaries of psychotic illness? (ii) Where do we position what we currently conceptualise and diagnose as schizophrenia within the much broader reality of psychotic disorder among those with serious mental illness and, indeed, of psychotic phenomena among the general population? (iii) To what extent are those components of psychotic illness that we resolve into separate diagnostic categories actually distinct in any fundamental way in terms of their epidemiological, clinical and pathobiological ‘signature’?
KeywordsBipolar Disorder Major Depressive Disorder Psychotic Disorder Bipolar Patient Schizoaffective Disorder
The Cavan–Monaghan First-Episode Study was supported initially by the Stanley Medical Research Institute and, subsequently, by Cavan–Monaghan Mental Health Service. Studies on the developmental pathobiology of psychosis are supported by Science Foundation Ireland. We thank the clinical teams and associated staff of Cavan–Monaghan Mental Health Service for their important contributions and Dr. Ronan Conroy, Department of Epidemiology, for assistance with incidence analyses.
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