Incidence and Outcome of Schizophrenia Across the Globe

Chapter

Abstract

Ten years ago, during the “IV Search for the Causes of Schizophrenia” meeting, one of the main issues regarding the epidemiology of schizophrenia was the meaning and implications of universality and uniformity in incidence rates for the disease in different places and cultures (Jablensky 1999; Eaton 1999). Most of the evidence upon which the interpretation of data and conclusions were based came from the “Ten Country Study”, coordinated by the World Health Organization (WHO) (Sartorius et al. 1986; Jablensky et al. 1992). In that study, also known as the “Determinants of Severe Mental Disorder” study (DOSMeD), incidence rate estimates were obtained for 8 of the 12 participating centres, two of which were from Chandigarh (urban and rural areas), in India. The study also generated relevant data on the outcome of schizophrenia in different cultures. Interpretation of the results from the “Ten Country Study” led to the widespread beliefs that the incidence of schizophrenia is similar across populations and cultures and that its prognosis is more favourable for persons who live in low- and middle-income countries (LAMICs) compared to those living in high-income countries, notions that can be seen in recent publications in the most prestigious scientific medical journals (e.g. Mueser and McGurk 2004).

Keywords

Migration Europe Income Schizophrenia Dunham 

Notes

Acknowledgment

PRM is partly funded by the CNPq-Brazil.

References

  1. Amminger, G. P., Harris, M. G., Conus, P., Lambert, M., Elkins, K. S., Yuen, H. P., Mcgorry, P. D. Treated incidence of first-episode psychosis in the catchment area of EPPIC between 1997 and 2000. Acta Psychiatrica Scandinavica 114: 337–345, 2006CrossRefPubMedGoogle Scholar
  2. Burns, J. K., Esterhuizen, T. Poverty, inequality and the treated incidence of first-episode psychosis. An ecological study from South Africa. Social Psychiatry and Psychiatric Epidemiology 43: 331–335, 2008CrossRefPubMedGoogle Scholar
  3. Cantor-Graae, E., Selten, J. P. Schizophrenia and migration: A meta-analysis and review. American Journal of Psychiatry 162: 12–24, 2005CrossRefPubMedGoogle Scholar
  4. Cohen, A., Patel, V., Thara, R., Gureje, O. Questioning an axiom: Better prognosis for schizophrenia in the developing world? Schizophrenia Bulletin 34: 229–244, 2008CrossRefPubMedGoogle Scholar
  5. Coid, J. W., Kirkbride, J. B., Barker, D., Cowden, F., Stamps, R., Yang, M., Jones, P. B. Raised incidence rates of all psychoses among migrant groups: Findings from the east London first episode psychosis study. Archives of General Psychiatry 65: 1250–1258, 2008CrossRefPubMedGoogle Scholar
  6. Corcoran, C., Perrin, M., Harlap, S., Deutsch, L., Fennig, S., Manor, O., Nahon, D., Kimhy, D., Malaspina, D., Susser, E. Incidence of schizophrenia among second-generation immigrants in the Jerusalem Perinatal Cohort. Schizophrenia Bulletin 2008 [epub ahead of printing]Google Scholar
  7. Eaton, W. W. Evidence for universality and uniformity of schizophrenia around the World: assessment and implications. In: Gattaz, W. F., Häfner, H. (eds.), Search or the Causes of Schizophrenia. Vol. IV Balance of the Century, Springer-Verlag, Berlin, pp. 21–33, 1999Google Scholar
  8. Faris, R., Dunham, H. Mental Disorders in Urban Areas. University of Chicago Press, Chicago, 1939Google Scholar
  9. Fearon, P., Kirkbride, J. B., Morgan, C., Dazzan, P., Morgan, K., Lloyd, T., Hutchinson, G., Tarrant, J., Lun Alan Fung, W., Holloway, J., Mallett, R., Harrison, G., Leff, J., Jones, P. B., Murray, R. M., Muga, F., Mietunen, J., Ashby, M., Hayhurst, H., Craig, T., Mccabe, J., Samele, C., Gwenzi, E., Sharpley, M., Vearnals, S., Hutchinson, G., Burnett, R., Kelly, J., Orr, K., Salvo, J., Greenwood, K., Raune, D., Lambri, M., Jones, S., Auer, S., Rohebak, P., Mcintosh, L., Doody, G., Window, S., Williams, P., Bagalkote, H., Dow, B., Boot, D., Farrant, A., Jones, S., Simpson, J., Moanette, R., Sirip Suranim, P. Z., Ruddell, M., Brewin, J., Medley, I. Incidence of schizophrenia and other psychoses in ethnic minority groups: Results from the MRC AESOP Study. Psychological Medicine 36: 1541–1550, 2006CrossRefPubMedGoogle Scholar
  10. Harrison, G., Hopper, K., Craig, T., Laska, E., Siegel, C., Wanderling, J., Dube, K. C., Ganev, K., Giel, R., An Der Heiden, W., Holmberg, S. K., Janca, A., Lee, P. W. H., León, C. A., Malhotra, S., Marsella, A. J., Nakane, Y., Sartorius, N., Shen, Y., Skoda, C., Thara, R., Tsirkin, S. J., Varma, V. K., Walsh, D., Wiersma, D. Recovery from psychotic illness: A 15- and 25-year international follow-up study. British Journal of Psychiatry 178: 506–517, 2001CrossRefPubMedGoogle Scholar
  11. Isaac, M., Chand, P., Murthy, P. Schizophrenia outcome measures in the wider international community. British Journal of Psychiatry 191(Suppl 50): s71–s77, 2007CrossRefGoogle Scholar
  12. Jablensky, A. The 100-year epidemiology of schizophrenia. In: Gattaz, W. F., Häfner, H. (eds.), Search for the Causes of Schizophrenia. Vol. IV Balance of the Century, Springer-Verlag, Berlin, pp. 3–19, 1999Google Scholar
  13. Jablensky, A., Sartorius, N., Ernberg, G., Anker, M., Korten, A., Cooper, J. E., Day, R., Bertelsen, A. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine Monograph Supplement 20: 1–97, 1992CrossRefPubMedGoogle Scholar
  14. Kirkbride, J. B., Barker, D., Cowden, F., Stamps, R., Yang, M., Jones, P. B., Coid, J. W. Psychoses, ethnicity and socio-economic status. British Journal of Psychiatry 193: 18–24, 2008CrossRefPubMedGoogle Scholar
  15. Kirkbride, J. B., Croudace, T., Brewin, J., Donoghue, K., Mason, P., Glazebrook, C., Medley, I., Harrison, G., Cooper, J. E., Doody, G. A., Jones, P. B. Is the incidence of psychotic disorder in decline? Epidemiological evidence from two decades of research. International Journal of Epidemiology 38(5): 1255–1264, 2008Google Scholar
  16. Kirkbride, J. B., Fearon, P., Morgan, C., Dazzan, P., Morgan, K., Tarrant, J., Lloyd, T., Holloway, J., Hutchinson, G., Leff, J. P., Mallett, R. M., Harrison, G. L., Murray, R. M., Jones, P. B. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: Findings from the 3-center ãSOP study. Archives of General Psychiatry 63: 250–258, 2006CrossRefPubMedGoogle Scholar
  17. Krabbendam, L., Van Os, J. Schizophrenia and urbanicity: A major environmental influence – Conditional on genetic risk. Schizophrenia Bulletin 31: 795–799, 2005CrossRefPubMedGoogle Scholar
  18. Leão, T. S., Sundquist, J., Frank, G., Johansson, L. M., Johansson, S. E., Sundquist, K. Incidence of schizophrenia or other psychoses in first- and second-generation immigrants: A National Cohort Study. Journal of Nervous and Mental Disease 194: 27–33, 2006CrossRefPubMedGoogle Scholar
  19. Marcelis, M., Takei, N., Van Os, J. Urbanization and risk for schizophrenia: Does the effect operate before or around the time of illness onset? Psychological Medicine 29: 1197–1203, 1999CrossRefPubMedGoogle Scholar
  20. March, D., Hatch, S. L., Morgan, C., Kirkbride, J. B., Bresnahan, M., Fearon, P., Susser, E. Psychosis and place. Epidemiologic Reviews 30: 84–100, 2008CrossRefPubMedGoogle Scholar
  21. Mcgrath, J., Saha, S., Welham, J., El Saadi, O., Maccauley, C., Chant, D. A systematic review of the incidence of schizophrenia: The distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Medicine 2, 2004Google Scholar
  22. Menezes, N. M., Arenovich, T., Zipursky, R. B. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychological Medicine 36: 1349–1362, 2006CrossRefPubMedGoogle Scholar
  23. Menezes, P. R., Scazufca, M., Busatto, G., Coutinho, L. M. S., Mcguire, P. K., Murray, R. M. Incidence of first-contact psychosis in São Paulo, Brazil. British Journal of Psychiatry 191(Suppl 51): s102–s106, 2007CrossRefGoogle Scholar
  24. Mueser, K. T., Mcgurk, S. R. Schizophrenia. Lancet 363: 2063–2072, 2004CrossRefPubMedGoogle Scholar
  25. Pedersen, C. B., Mortensen, P. B. Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk. Archives of General Psychiatry 58: 1039–1046, 2001CrossRefPubMedGoogle Scholar
  26. Saha, S., Chant, D. C., Welham, J. L., Mcgrath, J. J. The incidence and prevalence of schizophrenia varies with latitude. Acta Psychiatrica Scandinavica 114: 36–39, 2006aGoogle Scholar
  27. Saha, S., Welham, J., Chant, D., Mcgrath, J. Incidence of schizophrenia does not vary with economic status of the country: Evidence from a systematic review. Social Psychiatry and Psychiatric Epidemiology 41: 338–340, 2006bGoogle Scholar
  28. Sartorius, N., Jablensky, A., Korten, A., Ernberg, G., Anker, M., Cooper, J. E., Day, R. Early manifestations and first-contact incidence of schizophrenia in different cultures. A preliminary report on the initial evaluation phase of the WHO Collaborative Study on determinants of outcome of severe mental disorders. Psychological Medicine 16: 909–928, 1986CrossRefPubMedGoogle Scholar
  29. Selten, J. P., Zeyl, C., Dwarkasing, R., Lumsden, V., Kahn, R. S., Van Harten, P. N. First-contact incidence of schizophrenia in Surinam. British Journal of Psychiatry 186: 74–75, 2005CrossRefPubMedGoogle Scholar
  30. Weiser, M., Werbeloff, N., Vishna, T., Yoffe, R., Lubin, G., Shmushkevitch, M., Davidson, M. Elaboration on immigration and risk for schizophrenia. Psychological Medicine 38: 1113–1119, 2008CrossRefPubMedGoogle Scholar
  31. WHO Schizophrenia: An International Follow-Up Study. John Wiley and Sons, Chichester, 1979Google Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Departamento de Medicina Preventiva, Faculdade de MedicinaUniversidade de São PauloSão PauloBrazil

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