Target Pattern Recognition by Complement Proteins of the Classical and Alternative Pathways

  • Yu-Hoi Kang
  • Lee Aun Tan
  • Maria V. Carroll
  • Madeleine E. Gentle
  • Robert B. Sim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 653)


The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.


Complement Activation Classical Pathway Complement Protein Human Complement Complement Deficiency 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Yu-Hoi Kang
    • 2
  • Lee Aun Tan
    • 3
    • 4
  • Maria V. Carroll
    • 3
    • 5
  • Madeleine E. Gentle
    • 3
    • 4
  • Robert B. Sim
    • 1
  1. 1.Department of PharmacologyOxford UniversityOxfordUK
  2. 2.MRC Immunochemistry Unit Department of PharmacologyUniversity of OxfordOxfordUK
  3. 3.MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordOxfordUK
  4. 4.Division of Cell and Molecular BiologyImperial College LondonLondonUK
  5. 5.Department of PharmacologyUniversity of OxfordOxfordUK

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