Sporadic Medullary Thyroid Cancer

Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 153)

Abstract

Medullary thyroid cancer (MTC), is a tumor of the parafollicular / c-cells of the thyroid gland. These cells are derived from the embryonic neural crests and make up 1% of the thyroid cells. C-cells can be found anywhere in the gland but are concentrated in the upper poles of the thyroid lobes. Among other substances, these cells produce calcitonin which contributes to the regulation of serum calcium. This tumor, first described in 1959, is characterized by early spread to regional lymph nodes, and long-term survival even with disseminated disease [1]. Common sites of distant metastases include lung, liver, brain, bone, and soft tissue [2].

Keywords

Paclitaxel Catecholamine Imatinib Calcitonin Sorafenib 

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of SurgeryFoothills Medical CentreCalgaryCanada

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